Abstract
A drug discovery program aimed at identifying new antimalarial leads from a prefractionated natural product library has resulted in the purification of a new quinoline alkaloid, (2′R)-2′,3′-epoxy-N-methylatanine (1), along with eight known natural products, skimmianin (2), γ-fagarine (3), maculosidine (4), evolitrine (5), dictamnine (6), pteleine (7), N-methylatanine (8), and werneria chromene (9). Compound 1 displayed 74 % inhibition at 80 µM against a chloroquine-resistant Plasmodium falciparum strain (Dd2).
Key words
Drummondita calida
- Rutaceae - antimalaria - quinoline alkaloids - epoxide
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Prof. Dr. Ronald J. Quinn
Eskitis Institute, Griffith University
Nathan Campus
Brisbane, QLD 4111
Australia
Telefon: +61 7 37 35 60 00
Fax: +61 7 37 35 60 01
eMail: r.quinn@griffith.edu.au
