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Planta Med 2011; 77(14): 1651-1654
DOI: 10.1055/s-0030-1271027
Natural Product Chemistry
Letters
© Georg Thieme Verlag KG Stuttgart · New York

New Antimycobacterial Triterpenoids from Rhus taitensis

Raquel C. Jadulco1 , Michael Koch1 , Ryan M. Van Wagoner2 , Christopher Pond1 , Osia G. Gideon3 , Teatulohi Matainaho3 , Pius Piskaut4 , Louis R. Barrows1
  • 1Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah, USA
  • 2Department of Medicinal Chemistry, University of Utah, Salt Lake City, Utah, USA
  • 3School of Medicine and Health Sciences, University of Papua New Guinea, Boroko, NCD, Papua New Guinea
  • 4School of Natural and Physical Sciences, University of Papua New Guinea, Boroko, NCD, Papua New Guinea
Further Information

Publication History

received February 2, 2011 revised March 24, 2011

accepted March 29, 2011

Publication Date:
03 May 2011 (online)

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Abstract

Two new triterpenoids were isolated from the leaves and twigs of Rhus taitensis. Their structures were elucidated by 1D and 2D NMR spectroscopic studies as 1,10,24,25,30-pentahydroxysqualene (1) and dammar-20(22),24-diene-3β,26,27−triol (2). Both compounds exhibited moderate antimycobacterial activities with an MIC of 45 µg/mL.

Key words

pentahydroxysqualene - dammarane - triterpenoids - Rhus taitensis Guill. - Anacardiaceae - antimycobacterial

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Prof. Dr. Louis R. Barrows

Department of Pharmacology and Toxicology
University of Utah

30 S. 2000 E.

Salt Lake City, Utah 84112

USA

Phone: +1 80 15 82 45 47

Fax: +1 80 15 85 51 11

Email: lbarrows@pharm.utah.edu

    www.thieme-connect.de/ejournals/toc/plantamedica