St.-Gallen-Konferenz 2011 zum primären Mammakarzinom

Zusammenfassung

Alle 2 Jahre findet in St. Gallen die internationale Konsensuskonferenz zur Behandlung des primären Mammakarzinoms statt. Vor dem Hintergrund, dass das Konzept der St.-Gallen-Konsensuskonferenz v. a. ein internationales Meinungsbild widerspiegelt, erscheint es sinnvoll, die Abstimmungsergebnisse für den Therapiealltag in Deutschland zu konkretisieren. Eine Arbeitsgruppe von 28 Brustkrebsexperten, darunter 3 Mitglieder des internationalen St.-Gallen-Panels, hat daher die Abstimmungsergebnisse der diesjährigen St.-Gallen-Konsensuskonferenz (2011) aus deutscher Sicht kommentiert. Inhaltlicher Schwerpunkt der diesjährigen St.-Gallen-Konferenz war die Tumorbiologie als Ausgangspunkt für die individuelle Therapieentscheidung. Intensiver Diskussionsbedarf bestand bei der klinischen Relevanz prädiktiver und prognostischer Faktoren und den möglichen Konsequenzen für die Therapieentscheidung. So fokussierten insbesondere die Fragen zur Indikation einer adjuvanten Chemotherapie auf die Bedeutung des molekularen Phänotyps des Tumors. Wichtige Diskussionspunkte waren darüber hinaus der Stellenwert der kompletten Axilladissektion und der Einsatz der beschleunigten Gesamtbrustbestrahlung.

Abstract

Every 2 years, the International Consensus Conference on the Treatment of Primary Breast Cancer takes place in St. Gallen. Given that the concept of the St. Gallen Consensus Conference mainly reflects an international opinion, it appears useful to adapt the results of the vote for everyday therapy in Germany. A working group comprising 28 breast cancer experts, amongst whom there are 3 members of the international St. Gallen panel, has therefore commented on this year's St. Gallen Consensus Conference (2011) from the German viewpoint. The focus of interest of this year's St. Gallen Conference was tumour biology as the starting point for decisions regarding individual therapy. There was an intensive discussion in relation to the clinical relevance of predictive and prognostic factors and possible consequences for decisions regarding therapy. Therefore, questions concerning the indication for adjuvant chemotherapy focused especially on the significance of the molecular phenotype of the tumour. In addition, important points for discussion were also the value of complete axillary dissection and the use of accelerated complete breast irradiation.

Schlüsselwörter

frühes Mammakarzinom - endokrine Therapie - neoadjuvante Chemotherapie - zielgerichtete Therapie - prädiktive prognostische Marker

Key words

early breast cancer - endocrine therapy - neoadjuvant chemotherapy - targeted therapy - predictive prognostic marker

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