Two New Ginkgolides from the Leaves of Ginkgo biloba

Abstract

Two new diterpenoid compounds, ginkgolide P (1) and ginkgolide Q (2), were isolated from the leaves of Ginkgo biloba L. Their structures were elucidated by various spectroscopic methods, and the structure of 1 was further confirmed by X-ray crystallographic analysis. The activities of the compounds were evaluated against platelet aggregation induced by platelet activating factor (PAF), and the preliminary structure-activity relationship was also discussed.

Key words

Ginkgoaceae - Ginkgo biloba L. - ginkgolide P - ginkgolide Q - platelet activating factor

References

• 1 Gertz H J, Kiefer M. Review about Ginkgo biloba special extract EGb 761 (Ginkgo).  Curr Pharm Des. 2004;  10 261-264
• 2 Bikram S, Pushpinder K, Gopichand, Singh R D, Ahuja P S. Biology and chemistry of Ginkgo biloba.  Fitoterapia. 2008;  79 401-418
• 3 Stanislav J, Shahid M, Nakanishi K. Isolation of ginkgolides A, B, C, J and bilobalide from G. biloba extracts.  Phytochemistry. 2004;  65 2897-2902
• 4 Nakanishi K. Terpene trilactones from Gingko biloba: from ancient times to the 21st century.  Bioorg Med Chem. 2005;  13 4987-5000
• 5 Zhang X T, Li Y, Zhang L H, Qin M J. A new ginkgolide from Ginkgo biloba.  J China Pharm Univ. 2009;  40 306-309
• 6 Lou F C, Ling Y, Tang Y P, Wang Y. Isolation, purification and identification of Ginkgo terpene lactones.  Chin J Nat Med. 2004;  2 11-15
• 7 Li L, Li M, Shen Y M, Chen Z H, Du X B, Hao X J. Antipatelet aggregation activities of diterpene alkaloids from Spiraea fritschiana var. parvifolia.  Nat Prod Res Dev. 2002;  14 7-10