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Planta Med 2011; 77(16): 1829-1834
DOI: 10.1055/s-0030-1271196
Natural Product Chemistry
Original Papers
© Georg Thieme Verlag KG Stuttgart · New York

Three New Cycloartane Triterpenoids from Astragalus bicuspis

Saleem Jan1 , 3 , Ahmed Abbaskhan1 , Syed Ghulam Musharraf1 , Samina A. Sattar1 ,  Samreen1 , Saud I. Resayes2 , Zeid A. Al-Othman2 , Abdullah M. Al-Majid2 ,  Atta-ur-Rahman1 , M. Iqbal Choudhary1 , 2
  • 1H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan
  • 2Department of Chemistry, King Saud University, Riyadh, Saudi Arabia
  • 3Department of Chemistry, University of Science and Technology, Bannu, Pakistan
Further Information

Publication History

received March 10, 2011 revised May 10, 2011

accepted May 13, 2011

Publication Date:
15 July 2011 (online)

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Erratum for: Three New Cycloartane Triterpenoids from Astragalus bicuspisPlanta Med 2011; 77(16): E15-E15
DOI: 10.1055/s-0031-1280209

Abstract

Three new cycloartane triterpenoids have been isolated from Astragalus bicuspis Fisch. Their structures were elucidated as 23(R),24(S),25(R),26(S)-16β/23,23/26,24/25-triepoxy-26-hydroxy-9,19-cyclolanosta-3,6-dione (1), 6α,23,24,25-tetraol-16β-acetoxy-23(R),24(R)-9,19-cyclanosta-3-one (2), and 6α,23,24,25-tetraol-16β-acetoxy-23(R),24(R)-9,19-cyclolanosta-3β-O-xyloside (3), based on their spectroscopic analysis. All cycloartane tritepenoids exhibited weak cytotoxicities against 3T3 fibroblast cells as compared to the standard drug cycloheximide. Compounds 3 and 4 were also tested for their antileishmanial potential, and a weak activity was observed against promastigotes of Leishmania major.

Key words

Astragalus bicuspis - Leguminosae - cycloartane triterpenoids - antileishmanial activity - cytotoxicity - 3T3 fibroblast cell line

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Prof. M. Iqbal Choudhary

H. E. J. Research Institute of Chemistry
International Center for Chemical and Biological Sciences
University of Karachi

Karachi 75270

Pakistan

Phone: +92 21 48 24 92 45

Fax: +92 21 48 19 01 89

Email: hej@cyber.net.pk