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Int J Sports Med 2011; 32(6): 461-467
DOI: 10.1055/s-0031-1271697
Clinical Sciences

© Georg Thieme Verlag KG Stuttgart · New York

Exercise Training and Cytokines in Breast Cancer Survivors

A. M. Gómez1 , [*] , C. Martínez1 , [*] , C. Fiuza-Luces2 , F. Herrero3 , M. Pérez2 , L. Madero1 , J. R. Ruiz4 , 5 , A. Lucia2 , [*] , M. Ramírez1 , [*]
  • 1Hospital Infantil Universitario Niño Jesús, Oncologia, Madrid, Spain
  • 2Universidad Europea de Madrid, Biomedicine, Madrid, Spain
  • 3Ayuntamiento de Miranda de Ebro, Sports Medicine, Miranda, Spain
  • 4Unit for Preventive Nutrition, Karolinska Institutet, Department of Biosciences and Nutrition at NOVUM, Huddinge, Sweden
  • 5Department of Physical Activity and Sport Sciences, University of Granada, Spain
Further Information

Publication History

accepted after revision January 12, 2011

Publication Date:
04 March 2011 (online)

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Abstract

The purpose of this randomized controlled trial was to determine the effects of an 8-week (aerobic+strength) exercise training program (3 sessions/week) on the circulating cytokine levels of breast cancer survivors. We randomly allocated 16 female survivors of breast cancer (mean±SD age: 50±5 years) to an intervention or usual care (control) group (N=8 in each group). The intervention group followed an 8-week exercise program consisting of 3 sessions/week (session duration: 90 min). We measured the levels of the following cytokines before and after the intervention: beta-NGF, CTACK, eotaxin, FGF basic, G-CSF, gmCSFα, HGF, ICAM1, IFNα2, IFNγ, IL1α, IL1ß, IL1ra, IL2, IL2ra, IL3, IL4, IL6, IL7, IL8, IL9, IL10, IL12, IL13, IL15, IL16, IL17, IL18, IP10, LIF, MCS-F, MIP1α, MIP1β, MIF, MCP1, MCP3, MIG, PDGF bb, SCF, SCGFβ, SDF1α, TRAIL, TNFα, TNFβ, VCAM1, and VEGF. We only observed a significant interaction (group*time) effect for CTACK (P=0.016), with mean values remaining stable in the intervention group but increasing over time in controls. The intervention program did not induce a significant decrease in the main breast cancer-related cytokines such as IL6 and IL8. A combined (aerobic+strength) 8-week exercise training intervention did not induce major changes in the basal cytokine levels of breast cancer survivors.

Key words

physical activity - inflammation - tumour - interleukins

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1 A. M. Gómez and C. Martínez contributed equally to this paper and A. Lucia and A. Ramírez share senior authorship.

Correspondence

Prof. Alejandro Lucia

Universidad Europea De Madrid

Physiology

Villaviciosa de Odón

28670 Madrid

Spain

Phone: + 34/91/6647 800

Fax: + 34/91/6168 265

Email: alejandro.lucia@uem.es