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Eur J Pediatr Surg 2011; 21(3): 200-202
DOI: 10.1055/s-0031-1271734
DOI: 10.1055/s-0031-1271734
Case Gallery
© Georg Thieme Verlag KG Stuttgart · New York
Infantile Fibrosarcoma: 2 Case Reports and Literature Review
Further Information
Publication History
Publication Date:
18 February 2011 (online)
![](https://www.thieme-connect.de/media/ejps/201103/lookinside/thumbnails/10.1055-s-0031-1271734-1.jpg)
Introduction
Infantile fibrosarcoma (IFS) is a rare neoplasm. Although it accounts for less than 1% of all childhood cancers, it is the most common soft tissue neoplasm in infants under the age of one [1]. We reviewed 2 recent cases from our institution.
References
- 1 Sultan I, Casanova M, Al-Jumaily U. et al . Soft tissue sarcomas in the first year of life. Eur J Cancer. 2010; 46 2449-2456
- 2 Orbach D, Rey A, Cecchetto G. et al . Infantile fibrosarcoma: management based on the European experience. J Clin Oncol. 2010; 28 318-323
- 3 Kurkchubasche AG, Halvorson EG, Forman EN. et al . The role of preoperative chemotherapy in the treatment of infantile fibrosarcoma. J Pediatr Surg. 2000; 35 880-883
- 4 Corsi A, Boldrini R, Bosman C. Congenital-infantile fibrosarcoma: study of two cases and review of the literature. Tumori. 1994; 80 392-400
- 5 Ninane J, Gosseye S, Panteon E. et al . Congenital fibrosarcoma. Preoperative chemotherapy and conservative surgery. Cancer. 1986; 58 1400-1406
- 6 Chung EB, Enzinger FM. Infantile fibrosarcoma. Cancer. 1976; 38 729-739
- 7 Huang SY, Wang CW, Wang CJ. et al . Combined prenatal ultrasound and magnetic resonance imaging in an extensive congenital fibrosarcoma: a case report and review of the literature. Fetal Diagn Ther. 2005; 20 266-271
- 8 Stein-Wexler R. MR imaging of soft tissue masses in children. Magn Reson Imaging Clin N Am. 2009; 17 489-507
- 9 Wee A, Pho RW, Ong LB. Infantile fibrosarcoma: report of cases. Arch Pathol Lab Med. 1979; 103 236-238
- 10 McCahon E, Sorensen PH, Davis JH. et al . Non-resectable congenital tumors with the ETV6-NTRK3 gene fusion are highly responsive to chemotherapy. Med Pediatr Oncol. 2003; 40 288-292
- 11 Knezevich SR, Garnett MJ, Pysher TJ. et al . ETV6-NTRK3 gene fusions and trisomy 11 establish a histogenetic link between mesoblastic nephroma and congenital fibrosarcoma. Cancer Res. 1998; 58 5046-5048
- 12 Whittle S, Gosain A, Brown PY. et al . Regression of a congenital mesoblastic nephroma. Pediatr Blood Cancer. 2010; 55 364-368
- 13 Lannon CL, Sorensen PH. ETV6-NTRK3: a chimeric protein tyrosine kinase with transformation activity in multiple cell lineages. Semin Cancer Biol. 2005; 15 215-223
- 14 Bernstein R, Zeltzer PM, Lin F. et al . Trisomy 11 and other nonrandom trisomies in congenital fibrosarcoma. Cancer Genet Cytogenet. 1994; 78 82-86
- 15 Gorman PA, Malone M, Pritchard J. et al . Deletion of part of the short arm of chromosome 17 in a congenital fibrosarcoma. Cancer Genet Cytogenet. 1990; 48 193-198
- 16 Adem C, Gisselsson D, Dal Cin P. et al . ETV6 rearrangements in patients with infantile fibrosarcomas and congenital mesoblastic nephromas by fluorescence in situ hybridization. Mod Pathol. 2001; 14 1246-1251
- 17 Kothari KC, Pandey M, Wadhwa MK. et al . Congenital infantile fibrosarcoma. Eur J Surg Oncol. 1999; 25 94-96
- 18 Grier HE, Perez-Atayde AR, Weinstein HJ. Chemotherapy for inoperable infantile fibrosarcoma. Cancer. 1985; 56 1507-1510
- 19 Madden NP, Spicer RD, Allibone EB. et al . Spontaneous regression of neonatal fibrosarcoma. Br J Cancer Suppl. 1992; 18 S72-S75
Correspondence
Dr. Charles L SnyderMD
Children's Mercy Hosptial
Department of Surgery
24th and Gillham Rd
64108 Kansas City
United States
Phone: +1 816 234 3576
Fax: +1 913 983 6371
Email: csnyder@cmh.edu