Zusammenfassung
Die Tuberkulose (TB) rangiert nach wie vor unter den Infektionserkrankungen mit den weltweit höchsten Raten vermeidbarer Morbidität und Mortalität. Nur in den hochindustrialisierten Ländern, so auch in Deutschland mit 4400 Fällen im Jahr 2009 entsprechend einer Inzidenz von 5,5 pro 100 000 Einwohnern, ist ein anhaltend rückläufiger Trend zu beobachten. Parallel dazu nehmen die Konfrontation mit dieser Erkrankung und die klinische Erfahrung ab. Grundsätzlich kann die Tuberkulose jedes Organ befallen, in ca. 80 % der 2008 in Deutschland gemeldeten Fälle war die Lunge betroffen, in 20 % wurde eine extrapulmonale Manifestation registriert. Der Befall der Lymphknoten ist am häufigsten mit einem Anteil von ca. 50 % aller extrapulmonalen Tuberkulosen, gefolgt von der Pleura 18 %, des Urogenitaltraktes 13 %, der Knochen und Gelenke 6 %, des Gastrointestinaltraktes 6 %, des ZNS 3 % und der Wirbelsäule 3 %. Symptome wie Fieber, Nachtschweiß und Gewichtsverlust, sind unspezifisch und können gänzlich fehlen. Ziel der Übersichtsarbeit ist es, diese zunehmend in Vergessenheit geratende Erkrankung mit ihren vielfältigen radiologischen Manifestationen erneut ins Bewusstsein zu rücken und auf die klinisch-epidemiologischen und demografischen Faktoren hinzuweisen, welche den Verdacht auf eine Tuberkulose lenken.
Abstract
Tuberculosis (TB) continues to be one of the infectious diseases with the world’s highest rates of avoidable morbidity and mortality. A continuing downward trend has only been observed in highly industrialized countries, including Germany with 4,400 cases in the year 2009 representing an incidence of 5.5 per 100,000 persons. At the same time, the exposure to this patient group and the clinical experience are decreasing. Tuberculosis may affect any organ. The lung was the manifestation site in 80 % of cases, and extrapulmonary manifestations were recorded in 20 % of cases in Germany in the year 2008. Lymph node involvement is most common with a rate of approximately 50 % of all extrapulmonary cases followed by the pleura in 18 % of cases, genitourinary tract in 13 % of cases, bones and joints in 6 % of cases, gastrointestinal tract in 6 % of cases, the central nervous system in 3 % of cases and the spine in 3 % of cases. Symptoms like fever, night sweats and weight loss are non-specific and may be absent. The aim of the review is to raise awareness of this disease, which is increasingly falling into oblivion, with its various radiological manifestations and to point out clinical-epidemiological and demographic factors that raise suspicion of tuberculosis.
Key words
tuberculosis - extrapulmonary - X-ray - CT - MRI - differential diagnosis
Literatur
1 Global tuberculosis control: WHO report 2010. 2010
2 Tuberculosis country profiles: Germany. WHO. http://www.who.int/tb/country/data/profiles/en/index.html
3 Bericht zur Epidemiologie der Tuberkulose in Deutschland für 2008. Robert-Koch-Institut; 2008
4 Bericht zur Epidemiologie der Tuberkulose in Deutschland für 2007. Robert-Koch-Institut; 2007
5
Wallgren A.
The time-table of tuberculosis.
Tubercle.
1948;
29
245-251
6 Handbuch der Tuberkulose. Lungenliga Schweiz. http://www.tbinfo.ch/de/publikationen/handbuch-tuberkulose.html; Mai 2007
7 Hodder A The diagnosis of tuberculosis. In: Davies P D, Barnes P F, Gordon S B, (eds) Clinical Tuberculosis.. Fourth Edition. Hachette Livre, UK: Hodder Education; 2008: 79-89
8
Pai M, Zwerling A, Menzies D.
Systematic review: T-cell-based assays for the diagnosis of latent tuberculosis infection: an update.
Ann Intern Med.
2008;
149
177-184
9
Menzies D, Pai M, Comstock G.
Meta-analysis: new tests for the diagnosis of latent tuberculosis infection: areas of uncertainty and recommendations for research.
Ann Intern Med.
2007;
146
340-354
10 Hodder A mmunodiagnostic tests. In: Davies P D, Barnes P F, Gordon S B, (eds) Clinical Tuberculosis.. Fourth Edition. Hachette Livre, UK: Hodder Education; 2008: 91-103
11
Bhansali S K.
Abdominal tuberculosis. Experiences with 300 cases.
Am J Gastroenterol.
1977;
67
324-337
12
Manohar A, Simjee A E, Haffejee A A et al.
Symptoms and investigative findings in 145 patients with tuberculous peritonitis diagnosed by peritoneoscopy and biopsy over a five year period.
Gut.
1990;
31
1130-1132
13
Pereira J M, Madureira A J, Vieira A et al.
Abdominal tuberculosis: imaging features.
Eur J Radiol.
2005;
55
173-180
14
Kamper L, Piroth W, Haage P.
Knochentuberkulose im Klivus bei einem Jungen ohne pulmonale TBC-Manifestation.
Fortschr Röntgenstr.
2010;
182
715-716
15 Hodder A Clinical Tuberculosis. Fourth Edition. Hachette Livre, UK: Hodder Education; 2008: 163-188
16
Vaid S, Lee Y Y, Rawat S et al.
Tuberculosis in the head and neck – a forgotten differential diagnosis.
Clin Radiol.
2010;
65
73-81
17
Moon W K, Han M H, Chang K H et al.
CT and MR imaging of head and neck tuberculosis.
Radiographics.
1997;
17
391-402
18
Reede D L, Bergeron R T.
Cervical tuberculous adenitis: CT manifestations.
Radiology.
1985;
154
701-704
19
Im J G, Song K S, Kang H S et al.
Mediastinal tuberculous lymphadenitis: CT manifestations.
Radiology.
1987;
164
115-119
20
Figueiredo A A, Lucon A M, Arvellos A N et al.
A better understanding of urogenital tuberculosis pathophysiology based on radiological findings.
Eur J Radiol.
2010;
76
246-257
21
Gibson M S, Puckett M L, Shelly M E.
Renal tuberculosis.
Radiographics.
2004;
24
251-256
22
Engin G, Acunas B, Acunas G et al.
Imaging of extrapulmonary tuberculosis.
Radiographics.
2000;
20
471-488, quiz 529 – 430, 532
23
Zarrabi A D, Heyns C F.
Clinical features of confirmed versus suspected urogenital tuberculosis in region with extremely high prevalence of pulmonary tuberculosis.
Urology.
2009;
74
41-45
24
Figueiredo A A, Lucon A M.
Urogenital tuberculosis: update and review of 8961 cases from the world literature.
Rev Urol.
2008;
10
207-217
25
Browne R F, Zwirewich C, Torreggiani W C.
Imaging of urinary tract infection in the adult.
Eur Radiol.
2004;
14 Suppl 3
E168-E183
26
Harisinghani M G, McLoud T C, Shepard J A et al.
Tuberculosis from head to toe.
Radiographics.
2000;
20
449-470, quiz 528 – 549, 532
27
Vanhoenacker F M, De Backer A I, BB et al.
Imaging of gastrointestinal and abdominal tuberculosis.
Eur Radiol.
2004;
14 (Suppl 3)
E103-E115
28
Guo Y K, Yang Z G, Li Y et al.
Addison’s disease due to adrenal tuberculosis: contrast-enhanced CT features and clinical duration correlation.
Eur J Radiol.
2007;
62
126-131
29
Yang Z G, Guo Y K, Li Y et al.
Differentiation between tuberculosis and primary tumors in the adrenal gland: evaluation with contrast-enhanced CT.
Eur Radiol.
2006;
16
2031-2036
30
Wang J H, Sheu M H, Lee R C.
Tuberculosis of the prostate: MR appearance.
J Comput Assist Tomogr.
1997;
21
639-640
31
Tajima H, Tajima N, Hiraoka Y et al.
Tuberculosis of the prostate: MR imaging.
Radiat Med.
1995;
13
171-173
32
Wang J H, Chang T.
Tuberculosis of the prostate: CT appearance.
J Comput Assist Tomogr.
1991;
15
269-270
33
Sharma J B, Jain S K, Pushparaj M et al.
Abdomino-peritoneal tuberculosis masquerading as ovarian cancer: a retrospective study of 26 cases.
Arch Gynecol Obstet.
2010;
282
643-648
34
Zergeroglu S, Aydogdu T, Mollamahmutoglu L et al.
An uncommon adnexal mass: ovarian tuberculosis.
J Obstet Gynaecol.
2008;
28
755-756
35
Mannella P, Genazzani A R, Simoncini T.
Pelvic tuberculosis mimicking advanced ovarian cancer.
J Minim Invasive Gynecol.
2010;
17
143-145
36
Odejinmi F, Annan H G, Hussein S Y.
Tuberculosis, the great mimic again.A report of two cases of pelvic tuberculosis initially suspected to be advanced ovarian carcinoma.
J Obstet Gynaecol.
2000;
20
544-545
37
Jevtic V.
Vertebral infection.
Eur Radiol.
2004;
14 (Suppl 3)
E43-52
38
De Vuyst D, Vanhoenacker F, Gielen J et al.
Imaging features of musculoskeletal tuberculosis.
Eur Radiol.
2003;
13
1809-1819
39
Ahmadi J, Bajaj A, Destian S et al.
Spinal tuberculosis: atypical observations at MR imaging.
Radiology.
1993;
189
489-493
40
De Backer A I, Mortele K J, Vanhoenacker F M et al.
Imaging of extraspinal musculoskeletal tuberculosis.
Eur J Radiol.
2006;
57
119-130
41
Assadi M, Nabipour I, Eftekhari M et al.
Diagnostic role of whole body bone scintigraphy in atypical skeletal tuberculosis resembling multiple metastases: a case report.
J Med Case Reports.
2009;
3
141
42
Parmar H, Shah J, Patkar D et al.
Tuberculous arthritis of the appendicular skeleton: MR imaging appearances.
Eur J Radiol.
2004;
52
300-309
43
Akhan O, Pringot J.
Imaging of abdominal tuberculosis.
Eur Radiol.
2002;
12
312-323
44
Reddy K R, DiPrima R E, Raskin J B et al.
Tuberculous peritonitis: laparoscopic diagnosis of an uncommon disease in the United States.
Gastrointest Endosc.
1988;
34
422-426
45
Singh-Ranger D, Rockall T, Narward A H et al.
Abdominal tuberculosis: the problem of diagnostic delay.
Scand J Infect Dis.
1999;
31
517
46
Echenique Elizondo M, Amondarain Arratibel J, Compton C C et al.
Tuberculosis of the pancreas.
Surgery.
2001;
129
114-116
47
Eyal A S, Karusseit V O.
Tuberculosis of the pancreas mimicking carcinoma.
Int J Infect Dis.
2008;
12
108-110
48
Franco-Paredes C, Leonard M, Jurado R et al.
Tuberculosis of the pancreas: report of two cases and review of the literature.
Am J Med Sci.
2002;
323
54-58
49
Kouraklis G, Glinavou A, Karayiannakis A et al.
Primary tuberculosis of the pancreas mimicking a pancreatic tumor.
Int J Pancreatol.
2001;
29
151-153
50
Evans J D, Hamanaka Y, Olliff S P et al.
Tuberculosis of the pancreas presenting as metastatic pancreatic carcinoma. A case report and review of the literature.
Dig Surg.
2000;
17
183-187
51
De Backer A I, Mortele K J, Bomans P et al.
Tuberculosis of the pancreas: MRI features.
Am J Roentgenol.
2005;
184
50-54
52
Marshall J B.
Tuberculosis of the gastrointestinal tract and peritoneum.
Am J Gastroenterol.
1993;
88
989-999
53
Horvath K D, Whelan R L.
Intestinal tuberculosis: return of an old disease.
Am J Gastroenterol.
1998;
93
692-696
54
Thwaites G E, Schoeman J F.
Update on tuberculosis of the central nervous system: pathogenesis, diagnosis, and treatment.
Clin Chest Med.
2009;
30
745-754, ix
55
Joosten A A, Valk P D, Geelen J A et al.
Tuberculous meningitis: pitfalls in diagnosis.
Acta Neurol Scand.
2000;
102
388-394
56
Bernaerts van der A, Vanhoenacker F M, Parizel P M et al.
Tuberculosis of the central nervous system: overview of neuroradiological findings.
Eur Radiol.
2003;
13
1876-1890
57
Uysal G, Kose G, Guven A et al.
Magnetic resonance imaging in diagnosis of childhood central nervous system tuberculosis.
Infection.
2001;
29
148-153
Dr. Tobias Heye
Diagnostische und Interventionelle Radiologie, Radiologische Klinik, Universitätsklinikum Heidelberg
INF 110
69115 Heidelberg
Phone: ++ 49/62 21/5 63 93 91
Fax: ++ 49/62 21/56 57 30
Email: tobias.heye@med.uni-heidelberg.de