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DOI: 10.1055/s-0031-1273572
Antifungal Activity of Xanthones from Centaurium spicatum (Gentianaceae)
Centaurium spicatum L. is an erect little-branched annual herb, wide spread in Europe [1]. The chloroformic fraction of the roots of Centaurium spicatum L. afforded one new xanthone named 1,5,8-trihydroxy-3,6,7-trimethoxyxanthone (1) together with six known xanthones (2–7), one of them isolated for the first time from a plant source (2). The structures of the isolated compounds were established based on 1D and 2D (1H-1H COSY, HMQC, and HMBC) NMR spectroscopy, in addition to high resolution mass spectrometry. The isolated compounds were tested for their antimicrobial and antiprotozoal activities. Compound 6 displayed moderate antifungal activity against Candida krusei and C. neoformans with IC50 values of 12.8 and 17.9µg/mL respectively.
R1 |
R2 |
R3 |
R4 |
|
1 |
OH |
OCH3 |
OCH3 |
OH |
2 |
H |
OCH3 |
H |
OH |
3 |
OCH3 |
H |
H |
OCH3 |
4 |
OCH3 |
OCH3 |
OCH3 |
OCH3 |
5 |
OH |
H |
H |
H |
6 |
OCH3 |
OH |
H |
H |
7 |
OCH3 |
H |
H |
OH |
Acknowledgements: The authors are thankful to Dr. Bharanti Avula for the HRESIMS data and to Dr. Melissa Jacob for the antimicrobial testing.
References: [1] Everard B, (1969) Flowers of Europe, London Oxford University Press, New York, Toronto, 313–314.