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DOI: 10.1055/s-0031-1275343
© Georg Thieme Verlag KG Stuttgart · New York
Fetal Origin of Brain Damage in 2 Infants with a COL4A1 Mutation: Fetal and Neonatal MRI
Publication History
received 08.07.2011
accepted 09.03.2011
Publication Date:
15 April 2011 (online)
![](https://www.thieme-connect.de/media/neuropediatrics/201101/lookinside/thumbnails/10.1055-s-0031-1275343-1.jpg)
Abstract
Mutations in the gene COL4A1, encoding collagen IV A1, are associated with familial porencephaly. Previously, COL4A1 mutation-associated antenatal hemorrhages have been suggested by early post-natal imaging. We describe 2 children with fetal intracerebral hemorrhages and a COL4A1 mutation. There was also extensive hemispheric tissue loss in both infants and loss of cerebellar tissue in one infant. This paper show prenatal evidence of fetal hemorrhage in association with a COL4A1 mutation.
Key words
fetal intracerebral hemorrhage - porencephaly - COL4A1
References
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Notice:
This article was changed according to the following erratum on: 15.07.2011
Some of the authors' names of this article were incorrect. The names of the authors should be as follows: Vermeulen, R. J.; Peeters-Scholte, C.; Van Vugt, J. J. M. G.; Barkhof, F.; Rizzu, P.; van der Schoor, S. R. D.; van der Knaap, M. S.:
Correspondence
Assoc. Prof. R. Jeroen VermeulenMD, PhD
Department of Child Neurology
VU University Medical Center
De Boelelaan 1117
1081HV Amsterdam
The Netherlands
Phone: +31/20/444 4856
Fax: +31/20/444 0849
Email: rj.vermeulen@vumc.nl