Semin Respir Crit Care Med 2011; 32(2): 151-158
DOI: 10.1055/s-0031-1275527
© Thieme Medical Publishers

New Treatment Options for Infections Caused by Multiresistant Strains of Pseudomonas aeruginosa and Other Nonfermenting Gram-Negative Bacilli

Anna Sánchez1 , Simone Gattarello1 , Jordi Rello1 , 2
  • 1Critical Care Department, Vall d'Hebron University Hospital, Barcelona, Spain
  • 2CIBERES-VHIR-Universitat Autonome de Barcelona, Barcelona, Spain
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Publikationsdatum:
19. April 2011 (online)

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ABSTRACT

Hospital-acquired infections are one of the most important challenges to patient safety, especially in critical care units. The use of broad-spectrum antibiotics results frequently in multidrug-resistant pathogens. Therefore, we are attending to increased rates of multidrug-resistant microorganisms, especially gram-negative bacilli, that have been associated with prolonged hospital stays, higher costs, and increased mortality. The most important multidrug-resistant pathogens are Pseudomonas aeruginosa and Acinetobacter baumannii. There has been an important but as yet unsuccessful effort to develop new drugs to treat these pathogens. Nevertheless, old, very well known drugs, such as polymyxins, administered intravenously and aerosolized, have been revisited. Future options include immunotherapy or the continuous infusion of antibiotics. It is also important to emphasize the rational use of antibiotics to diminish the appearance of multiresistant pathogens.

REFERENCES

Anna SánchezM.D. 

Critical Care Department, Vall d'Hebron University Hospital

Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain

eMail: ana_sanchez_corral@hotmail.com