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DOI: 10.1055/s-0031-1275638
Temporal Chondroblastoma with a Novel Chromosomal Translocation (2;5) (q33;q13)
Publication History
Publication Date:
25 March 2011 (online)
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ABSTRACT
The case of a 51-year-old man with a large temporal mass is presented. The mass eroded the floor of the middle fossa medially to the sphenoid sinus. A combined approach with neurosurgery and otolaryngology was performed to achieve maximal resection of the mass. Pathology was typical for chondroblastoma: a rare, benign but locally invasive chondroid tumor. Genetic testing revealed a translocation of (2;5) (q33;q13). This is a unique genetic mutation in all chondroid tumors to our knowledge. The diagnostic utility or role of this mutation in the pathobiology of this tumor remains to be determined.
KEYWORDS
Chondroblastoma - genetics - karyotype - temporal bone - skull-base tumor - cytogenetics
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Rafael Medina-FloresM.D.
Department of Pathology, MSC08-4640
1 University of New Mexico, Albuquerque, NM 87131
Email: rmedina-flores@salud.unm.edu