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DOI: 10.1055/s-0031-1275704
© Georg Thieme Verlag KG Stuttgart · New York
Pioglitazone Compared to Glibenclamide on Lipid Profile and Inflammation Markers in Type 2 Diabetic Patients During an Oral Fat Load
Publikationsverlauf
received 07.02.2011
accepted 22.03.2011
Publikationsdatum:
17. Mai 2011 (online)
![](https://www.thieme-connect.de/media/hmr/201107/lookinside/thumbnails/10.1055-s-0031-1275704-1.jpg)
Abstract
The aim of the study was to evaluate the effect of pioglitazone and glibenclamide on lipid profile and inflammatory parameters during an oral fat load (OFL). A total of 201 type 2 diabetic patients on treatment with metformin were enrolled in the study; pioglitazone was titrated till 45 mg/day and glibenclamide till 15 mg/day, in association with metformin, respectively. The patients underwent an OFL at baseline and after 12 months. The OFL was given between 08.00 and 09.00 h after a 12-h fast. Blood samples were drawn before and 3, 6, 9, and 12 h after the OFL. We evaluated glycemic-metabolic parameters [glycated hemoglobin (HbA1c), fasting plasma glucose (FPG), fasting plasma insulin (FPI), homeostasis model assessment (Homa) index], total cholesterol (TC), low density lipoprotein-cholesterol (LDL-C), high density lipoprotein-cholesterol (HDL-C), triglycerides (Tgs), interleukin-6 (IL-6), high sensitivity C-reactive protein (Hs-CRP), tumor necrosis factor-α (TNF-α), and adiponectin (ADN). Pioglitazone was better than glibenclamide in decreasing HbA1c, FPG, FPI, lipid profile, and in improving inflammatory parameters such as Hs-CRP, and ADN. Comparing the OFL performed at baseline, and the OFL performed at the end of the study, pioglitazone, but not glibenclamide, improved all post-OFL peaks for all parameters. Comparing the 12 months OFL in the group treated with pioglitazone and in the group treated with glibenclamide, the values recorded with pioglitazone were significantly better than the ones obtained with glibenclamide. We can conclude that pioglitazone was better than glibenclamide in mitigating the variations of lipid components and inflammation parameters in type 2 diabetic patients.
Key words
pioglitazone - glibenclamide - type 2 diabetes mellitus - oral fat load - inflammation
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Correspondence
G. DerosaMD, PhD
Department of Internal
Medicine and Therapeutics
University of Pavia
P. le C. Golgi 2
27100 Pavia
Italy
Telefon: +39/0382/5262 17
Fax: +39/0382/5262 59
eMail: giuseppe.derosa@unipv.it