Subscribe to RSS
DOI: 10.1055/s-0031-1277004
Ernährung von Intensivpatienten
Nutrition of the Critically IllPublication History
Publication Date:
14 February 2012 (online)
Zusammenfassung
Mangelernährung ist ein häufiges und outcomerelevantes Problem auf der Intensivstation. Bei kritisch Kranken verschlechtert sich der Ernährungszustand bei vielen Patienten als Konsequenz des Stressstoffwechsels und einer inadäquaten Substratzufuhr weiter. Die klinische, an den Stoffwechsel des kritisch Kranken adaptierte Ernährung ist die einzige spezifische Therapie einer manifesten oder drohenden Mangelernährung. Dabei muss der Fokus darauf liegen, eine Hyperalimentation in der Frühphase und eine Hypoalimentation in der prolongierten Phase des Intensivaufenthalts zu vermeiden. Zusätzlich werden Omega-3-Fettsäuren und Antioxidanzien auf enteralem Weg bei ARDS (Adult Respiratory Distress Syndrome) empfohlen. Bei Indikation zu einer parenteralen Ernährung soll parenterales Glutamin hoch dosiert verabreicht werden.
Abstract
Malnutrition occurs frequently in the ICU influencing clinical outcome in critically ill patients. As a consequence of stress metabolism and inadequate intake, nutritional status deteriorates in most critically ill patients during their ICU stay. Artificial nutritional support is the only specific therapy to overcome the metabolic consequences of malnutrition. In critically ill patients priority must be given to avoid hyperalimentation in the early phase and hypoalimentation in the prolonged phase of an ICU stay. In ARDS patients, supplementation of enteral diet enriched with omega-3-fatty acids and antioxidants improved outcome. Whenever parenteral nutrition is indicated, high dose parenteral glutamine supplementation should be applied.
Schlüsselwörter
Ernährung - enteral - parenteral - Immunmodulation
Keywords
nutrition - enteral - parenteral - immunomodulation
Literatur
- 1 Löser C. Unter- / Mangelernährung im Krankenhaus. Aktuel Ernahrungsmed. 2011; 36 57-77
- 2 McWhirter J P, Pennington C R. Incidence and recognition of malnutrition in hospital. BMJ. 1994; 308 945-948
- 3 Stratton R, Green C, Elia M. Disease-related malnutrition: an evidence-based approach to treatment. Oxon: CABI Publishing; 2003
- 4 Kondrup J, Rasmussen H H, Hamberg O et al. Nutritional risk screening (NRS 2002): a new method based on an analysis of controlled clinical trials. Clin Nutr. 2003; 22 321-336
- 5 Hill G L, Blackett R L, Pickford I et al. Malnutrition in surgical patients. An unrecognised problem. Lancet. 1977; 1 689-692
- 6 Lennard-Jones J E, Arrowsmith H, Davison C et al. Screening by nurses and junior doctors to detect malnutrition when patients are first assessed in hospital. Clin Nutr. 1995; 14 336-340
- 7 Pirlich M, Schutz T, Norman K et al. The German hospital malnutrition study. Clin Nutr. 2006; 25 563-572
- 8 Giner M, Laviano A, Meguid M M et al. In 1995 a correlation between malnutrition and poor outcome in critically ill patients still exists. Nutrition. 1996; 12 23-29
- 9 Sorensen J, Kondrup J, Prokopowicz J et al. EuroOOPS: an international, multicentre study to implement nutritional risk screening and evaluate clinical outcome. Clin Nutr. 2008; 27 340-349
- 10 Lenz A, Franklin G A, Cheadle W G. Systemic inflammation after trauma. Injury. 2007; 38 1336-1345
- 11 Bone R C. Sir Isaac Newton, sepsis, SIRS, and CARS. Crit Care Med. 1996; 24 1125-1128
- 12 Black P R, Brooks D C, Bessey P Q et al. Mechanisms of insulin resistance following injury. Ann Surg. 1982; 196 420-435
- 13 Randle P J, Garland P B, Hales C N et al. The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet. 1963; 1 785-789
- 14 Askanazi J, Elwyn D H, Silverberg P A et al. Respiratory distress secondary to a high carbohydrate load: a case report. Surgery. 1980; 87 596-598
- 15 Stoner H B, Little R A, Frayn K N et al. The effect of sepsis on the oxidation of carbohydrate and fat. Br J Surg. 1983; 70 32-35
- 16 Nordenstrom J, Carpentier Y A, Askanazi J et al. Metabolic utilization of intravenous fat emulsion during total parenteral nutrition. Ann Surg. 1982; 196 221-231
- 17 Singer P, Berger M M, van den Berghe G et al. ESPEN Guidelines on Parenteral Nutrition: intensive care. Clin Nutr. 2009; 28 387-400
- 18 Elia M. The effects of nitrogen and energy intake on the metabolism of normal, depleted and injured man: considerations for practical nutritional support. Clin Nutr. 1982; 1 173-192
- 19 Felbinger T W, Suchner U. Ernährungsstrategien bei kritisch kranken Patienten. Anaesthesie & Intensivmedizin. 2000; 41 206-222
- 20 Loser C. Malnutrition in the hospital--prevalence, clinical consequences, economic relevance. Dtsch Med Wochenschr. 2001; 126 729-734
- 21 Akinnusi M E, Pineda L A, El Solh A A. Effect of obesity on intensive care morbidity and mortality: a meta-analysis. Crit Care Med. 2008; 36 151-158
- 22 Correia M I, Waitzberg D L. The impact of malnutrition on morbidity, mortality, length of hospital stay and costs evaluated through a multivariate model analysis. Clin Nutr. 2003; 22 235-239
- 23 Memtsoudis S G, Bombardieri A M, Ma Y et al. Mortality of Patients With Respiratory Insufficiency and Adult Respiratory Distress Syndrome After Surgery: The Obesity Paradox. J Intensive Care Med. 2011; (ahead of print)
- 24 Atalay B G, Yagmur C, Nursal T Z et al. Use of subjective global assessment and clinical outcomes in critically ill geriatric patients receiving nutrition support. JPEN J Parenter Enteral Nutr. 2008; 32 454-459
- 25 Gamrin L, Essen P, Hultman E et al. Protein-sparing effect in skeletal muscle of growth hormone treatment in critically ill patients. Ann Surg. 2000; 231 577-586
- 26 Felbinger T W, Suchner U, Goetz A E et al. Recombinant human growth hormone for reconditioning of respiratory muscle after lung volume reduction surgery. Crit Care Med. 1999; 27 1634-1638
- 27 Pichard C, Kyle U G, Jolliet P et al. Treatment of cachexia with recombinant growth hormone in a patient before lung transplantation: a case report. Crit Care Med. 1999; 27 1639-1642
- 28 Takala J, Ruokonen E, Webster N R et al. Increased mortality associated with growth hormone treatment in critically ill adults. N Engl J Med. 1999; 341 785-792
- 29 Dudrick S J, Wilmore D W, Vars H M et al. Long-term total parenteral nutrition with growth, development, and positive nitrogen balance. 1968. Nutr Hosp. 2001; 16 287-292; discussion 286–287
- 30 Burke J F, Wolfe R R, Mullany C J et al. Glucose requirements following burn injury. Parameters of optimal glucose infusion and possible hepatic and respiratory abnormalities following excessive glucose intake. Ann Surg. 1979; 190 274-285
- 31 Garrel D R, Jobin N, de Jonge L H. Should we still use the Harris and Benedict equations?. Nutr Clin Pract. 1996; 11 99-103
- 32 Douglas C C, Lawrence J C, Bush N C et al. Ability of the Harris Benedict formula to predict energy requirements differs with weight history and ethnicity. Nutr Res. 2007; 27 194-199
- 33 Ogawa A M, Shikora S A, Burke L M et al. The thermodilution technique for measuring resting energy expenditure does not agree with indirect calorimetry for the critically ill patient. JPEN J Parenter Enteral Nutr. 1998; 22 347-351
- 34 Egi M, Bellomo R, Stachowski E et al. Blood glucose concentration and outcome of critical illness: the impact of diabetes. Crit Care Med. 2008; 36 2249-2255
- 35 Fogelholm R, Murros K, Rissanen A et al. Admission blood glucose and short-term survival in primary intracerebral haemorrhage: a population based study. J Neurol Neurosurg Psychiatry. 2005; 76 349-353
- 36 Worthley M I, Shrive F M, Anderson T J et al. Prognostic implication of hyperglycemia in myocardial infarction and primary angioplasty. Am J Med. 2007; 120 643
- 37 Krishnan J A, Parce P B, Martinez A et al. Caloric intake in medical ICU patients: consistency of care with guidelines and relationship to clinical outcomes. Chest. 2003; 124 297-305
- 38 Casaer M P, Mesotten D, Hermans G et al. Early versus late parenteral nutrition in critically ill adults. N Engl J Med. 2011; 365 506-517
- 39 Ibrahim E H, Mehringer L, Prentice D et al. Early versus late enteral feeding of mechanically ventilated patients: results of a clinical trial. JPEN J Parenter Enteral Nutr. 2002; 26 174-181
- 40 Villet S, Chiolero R L, Bollmann M D et al. Negative impact of hypocaloric feeding and energy balance on clinical outcome in ICU patients. Clin Nutr. 2005; 24 502-509
- 41 Faisy C, Lerolle N, Dachraoui F et al. Impact of energy deficit calculated by a predictive method on outcome in medical patients requiring prolonged acute mechanical ventilation. Br J Nutr. 2009; 101 1079-1087
- 42 Drover J W, Cahill N E, Kutsogiannis J et al. Nutrition therapy for the critically ill surgical patient: we need to do better!. JPEN J Parenter Enteral Nutr. 2010; 34 644-652
- 43 Kreymann K G, de Heer G, Felbinger T et al. Nutrition of critically ill patients in intensive care. Internist (Berl). 2007; 48 1084-1092
- 44 Berger M M, Soguel L. Feed the ICU patient ‘gastric’ first, and go post-pyloric only in case of failure. Crit Care. 2010; 14 123
- 45 Heyland D K, Dhaliwal R, Suchner U et al. Antioxidant nutrients: a systematic review of trace elements and vitamins in the critically ill patient. Intensive Care Med. 2005; 31 327-337
- 46 Artinian V, Krayem H, DiGiovine B. Effects of early enteral feeding on the outcome of critically ill mechanically ventilated medical patients. Chest. 2006; 129 960-967
- 47 Reignier J, Dimet J, Martin-Lefevre L et al. Before-after study of a standardized ICU protocol for early enteral feeding in patients turned in the prone position. Clin Nutr. 2010; 29 210-216
- 48 Khalid I, Doshi P, DiGiovine B. Early enteral nutrition and outcomes of critically ill patients treated with vasopressors and mechanical ventilation. Am J Crit Care. 2010; 19 261-268
- 49 Zaloga G P, Roberts P R, Marik P. Feeding the hemodynamically unstable patient: a critical evaluation of the evidence. Nutr Clin Pract. 2003; 18 285-293
- 50 Simpson F, Doig G S. Parenteral vs. enteral nutrition in the critically ill patient: a meta-analysis of trials using the intention to treat principle. Intensive Care Med. 2005; 31 12-23
- 51 Marik P E, Pinsky M. Death by parenteral nutrition. Intensive Care Med. 2003; 29 867-869
- 52 Dhaliwal R, Jurewitsch B, Harrietha D et al. Combination enteral and parenteral nutrition in critically ill patients: harmful or beneficial? A systematic review of the evidence. Intensive Care Med. 2004; 30 1666-1671
- 53 Singer P, Shapiro H, Bendavid I. Behind the ESPEN Guidelines on parenteral nutrition in the ICU. Minerva Anestesiol. 2011; 77 1115-1120
- 54 Kreymann K G, Adolph M, Druml W et al. Intensivmedizinische Leitlinie parenterale Ernährung der DGEM. Aktuel Ernahrungsmed. 2007; 32 S89-S92
- 55 Reid C. Frequency of under- and overfeeding in mechanically ventilated ICU patients: causes and possible consequences. J Hum Nutr Diet. 2006; 19 13-22
- 56 Griesdale D E, de Souza R J, van Dam R M et al. Intensive insulin therapy and mortality among critically ill patients: a meta-analysis including NICE-SUGAR study data. CMAJ. 2009; 180 821-827
- 57 Wiener R S, Wiener D C, Larson R J. Benefits and risks of tight glucose control in critically ill adults: a meta-analysis. JAMA. 2008; 300 933-944
- 58 Langouche L, Vanhorebeek I, van den Berghe G. Therapy insight: the effect of tight glycemic control in acute illness. Nat Clin Pract Endocrinol Metab. 2007; 3 270-278
- 59 Vriesendorp T M, DeVries J H, van Santen S et al. Evaluation of short-term consequences of hypoglycemia in an intensive care unit. Crit Care Med. 2006; 34 2714-2718
- 60 Vriesendorp T M, van Santen S, DeVries J H et al. Predisposing factors for hypoglycemia in the intensive care unit. Crit Care Med. 2006; 34 96-101
- 61 Chen B, Zhou Y, Yang P et al. Safety and efficacy of fish oil-enriched parenteral nutrition regimen on postoperative patients undergoing major abdominal surgery: a meta-analysis of randomized controlled trials. JPEN J Parenter Enteral Nutr. 2010; 34 387-394
- 62 Krinsley J S. Glycemic variability in critical illness and the end of Chapter 1. Crit Care Med. 2010; 38 1206-1208
- 63 Harris H W, Grunfeld C, Feingold K R et al. Chylomicrons alter the fate of endotoxin, decreasing tumor necrosis factor release and preventing death. J Clin Invest. 1993; 91 1028-1034
- 64 Read T E, Grunfeld C, Kumwenda Z L et al. Triglyceride-rich lipoproteins prevent septic death in rats. J Exp Med. 1995; 182 267-272
- 65 Kreymann K G, Berger M M, Deutz N E et al. ESPEN Guidelines on Enteral Nutrition: Intensive care. Clin Nutr. 2006; 25 210-223
- 66 Montejo J C, Minambres E, Bordeje L et al. Gastric residual volume during enteral nutrition in ICU patients: the REGANE study. Intensive Care Med. 2010; 36 1386-1393
- 67 Davies A R. Gastric residual volume in the ICU: can we do without measuring it?. JPEN J Parenter Enteral Nutr. 2010; 34 160-162
- 68 Cahill N E, Dhaliwal R, Day A G et al. Nutrition therapy in the critical care setting: what is „best achievable“ practice? An international multicenter observational study. Crit Care Med. 2010; 38 395-401
- 69 Clifford M E, Banks M D, Ross L J et al. A detailed feeding algorithm improves delivery of nutrition support in an intensive care unit. Crit Care Resusc. 2010; 12 149-155
- 70 Martin C M, Doig G S, Heyland D K et al. Multicentre, cluster-randomized clinical trial of algorithms for critical-care enteral and parenteral therapy (ACCEPT). CMAJ. 2004; 170 197-204
- 71 Brown R O, Hunt H, Mowatt-Larssen C A et al. Comparison of specialized and standard enteral formulas in trauma patients. Pharmacotherapy. 1994; 14 314-320
- 72 Moore F A, Moore E E, Kudsk K A et al. Clinical benefits of an immune-enhancing diet for early postinjury enteral feeding. J Trauma. 1994; 37 607-615
- 73 Kudsk K A, Li J, Renegar K B. Loss of upper respiratory tract immunity with parenteral feeding. Ann Surg. 1996; 223 629-635; discussion 635–628
- 74 Weimann A, Bastian L, Bischoff W E et al. Influence of arginine, omega-3 fatty acids and nucleotide-supplemented enteral support on systemic inflammatory response syndrome and multiple organ failure in patients after severe trauma. Nutrition. 1998; 14 165-172
- 75 Mendez C, Jurkovich G J, Garcia I et al. Effects of an immune-enhancing diet in critically injured patients. J Trauma. 1997; 42 933-940; discussion 940–931
- 76 Heyland D K, Novak F, Drover J W et al. Should immunonutrition become routine in critically ill patients? A systematic review of the evidence. JAMA. 2001; 286 944-953
- 77 Wischmeyer P. Nutritional pharmacology in surgery and critical care: ‘you must unlearn what you have learned’. Curr Opin Anaesthesiol. 2011; 24 381-388
- 78 McCowen K C, Bistrian B R. Immunonutrition: problematic or problem solving?. Am J Clin Nutr. 2003; 77 764-770
- 79 Heller A R, Fischer S, Rossel T et al. Impact of n-3 fatty acid supplemented parenteral nutrition on haemostasis patterns after major abdominal surgery. Br J Nutr. 2002; 87 (S 01) S95-101
- 80 Lee J Y, Sohn K H, Rhee S H et al. Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4. J Biol Chem. 2001; 276 16 683-16 689
- 81 Serhan C N, Chiang N, Van Dyke T E. Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators. Nat Rev Immunol. 2008; 8 349-361
- 82 Serhan C N, Savill J. Resolution of inflammation: the beginning programs the end. Nat Immunol. 2005; 6 1191-1197
- 83 Marik P E, Zaloga G P. Immunonutrition in critically ill patients: a systematic review and analysis of the literature. Intensive Care Med. 2008; 34 1980-1990
- 84 Gadek J E, DeMichele S J, Karlstad M D et al. Effect of enteral feeding with eicosapentaenoic acid, gamma-linolenic acid, and antioxidants in patients with acute respiratory distress syndrome. Enteral Nutrition in ARDS Study Group. Crit Care Med. 1999; 27 1409-1420
- 85 Pontes-Arruda A, Aragao A M, Albuquerque J D. Effects of enteral feeding with eicosapentaenoic acid, gamma-linolenic acid, and antioxidants in mechanically ventilated patients with severe sepsis and septic shock. Crit Care Med. 2006; 34 2325-2333
- 86 Singer P, Theilla M, Fisher H et al. Benefit of an enteral diet enriched with eicosapentaenoic acid and gamma-linolenic acid in ventilated patients with acute lung injury. Crit Care Med. 2006; 34 1033-1038
- 87 Stapleton R D, Martin T R, Weiss N S et al. A phase II randomized placebo-controlled trial of omega-3 fatty acids for the treatment of acute lung injury. Crit Care Med. 2011; 39 1655-1662
- 88 Rice T W, Wheeler A P, Thompson B T et al. Enteral omega-3 fatty acid, gamma-linolenic acid, and antioxidant supplementation in acute lung injury. JAMA. 2011; 306 1574-1581
- 89 Wernerman J. Role of glutamine supplementation in critically ill patients. Curr Opin Anaesthesiol. 2008; 21 155-159
- 90 Roth E. Nonnutritive effects of glutamine. J Nutr. 2008; 138 2025S-2031S
- 91 Wernerman J. Glutamine and acute illness. Curr Opin Crit Care. 2003; 9 279-285
- 92 Wischmeyer P E. Clinical applications of L-glutamine: past, present, and future. Nutr Clin Pract. 2003; 18 377-385
- 93 Singleton K D, Wischmeyer P E. Glutamine induces heat shock protein expression via O-glycosylation and phosphorylation of HSF-1 and Sp1. JPEN J Parenter Enteral Nutr. 2008; 32 371-376
- 94 Garcia-de-Lorenzo A, Zarazaga A, Garcia-Luna P P et al. Clinical evidence for enteral nutritional support with glutamine: a systematic review. Nutrition. 2003; 19 805-811
- 95 Houdijk A P, Rijnsburger E R, Jansen J et al. Randomised trial of glutamine-enriched enteral nutrition on infectious morbidity in patients with multiple trauma. Lancet. 1998; 352 772-776
- 96 Conejero R, Bonet A, Grau T et al. Effect of a glutamine-enriched enteral diet on intestinal permeability and infectious morbidity at 28 days in critically ill patients with systemic inflammatory response syndrome: a randomized, single-blind, prospective, multicenter study. Nutrition. 2002; 18 716-721
- 97 Zhou Y P, Jiang Z M, Sun Y H et al. The effect of supplemental enteral glutamine on plasma levels, gut function, and outcome in severe burns: a randomized, double-blind, controlled clinical trial. JPEN J Parenter Enteral Nutr. 2003; 27 241-245
- 98 Singleton K D, Wischmeyer P E et al. Glutamine’s protection against sepsis and lung injury is dependent on heat shock protein 70 expression. Am J Physiol Regul Integr Comp Physiol. 2007; 292 R1839-1845
- 99 Hall J C, Dobb G, Hall J et al. A prospective randomized trial of enteral glutamine in critical illness. Intensive Care Med. 2003; 29 1710-1716
- 100 Jones C, Palmer T E, Griffiths R D. Randomized clinical outcome study of critically ill patients given glutamine-supplemented enteral nutrition. Nutrition. 1999; 15 108-115
- 101 Griffiths R D, Jones C, Palmer T E. Six-month outcome of critically ill patients given glutamine-supplemented parenteral nutrition. Nutrition. 1997; 13 295-302
- 102 Goeters C, Wenn A, Mertes N et al. Parenteral L-alanyl-L-glutamine improves 6-month outcome in critically ill patients. Crit Care Med. 2002; 30 2032-2037
- 103 Novak F, Heyland D K, Avenell A et al. Glutamine supplementation in serious illness: a systematic review of the evidence. Crit Care Med. 2002; 30 2022-2029
- 104 Tjader I, Rooyackers O, Forsberg A M et al. Effects on skeletal muscle of intravenous glutamine supplementation to ICU patients. Intensive Care Med. 2004; 30 266-275
- 105 Heyland D K, Dhaliwal R, Day A G et al. REducing Deaths due to OXidative Stress (The REDOXS Study): Rationale and study design for a randomized trial of glutamine and antioxidant supplementation in critically-ill patients. Proc Nutr Soc. 2006; 65 250-263
- 106 Jones N E, Heyland D K. Pharmaconutrition: a new emerging paradigm. Curr Opin Gastroenterol. 2008; 24 215-222
- 107 Berger M M, Chiolero R L. Antioxidant supplementation in sepsis and systemic inflammatory response syndrome. Crit Care Med. 2007; 35 S584-590
- 108 Angstwurm M W, Gaertner R. Practicalities of selenium supplementation in critically ill patients. Curr Opin Clin Nutr Metab Care. 2006; 9 233-238
- 109 Forceville X, Laviolle B, Annane D et al. Effects of high doses of selenium, as sodium selenite, in septic shock: a placebo-controlled, randomized, double-blind, phase II study. Crit Care. 2007; 11 R73
- 110 Heyland D K. Selenium supplementation in critically ill patients: can too much of a good thing be a bad thing?. Crit Care. 2007; 11 153
- 111 Avenell A, Noble D W, Barr J et al. Selenium supplementation for critically ill adults. Cochrane Database Syst Rev 2004; CD003703
- 112 Andrews P J, Avenell A, Noble D W et al. Randomised trial of glutamine, selenium, or both, to supplement parenteral nutrition for critically ill patients. BMJ. 2011; 342 d1542
- 113 Popovic P J, Zeh 3rd H J, Ochoa J B. Arginine and immunity. J Nutr. 2007; 137 1681S-1686S
- 114 Bower R H, Cerra F B, Bershadsky B et al. Early enteral administration of a formula (Impact) supplemented with arginine, nucleotides, and fish oil in intensive care unit patients: results of a multicenter, prospective, randomized, clinical trial. Crit Care Med. 1995; 23 436-449
- 115 Bertolini G, Iapichino G, Radrizzani D et al. Early enteral immunonutrition in patients with severe sepsis: results of an interim analysis of a randomized multicentre clinical trial. Intensive Care Med. 2003; 29 834-840
- 116 Drover J W, Dhaliwal R, Weitzel L et al. Perioperative use of arginine-supplemented diets: a systematic review of the evidence. J Am Coll Surg. 2011; 212 385-399, 399 e381
- 117 Ligthart-Melis G C, van de Poll M C, Boelens P G et al. Glutamine is an important precursor for de novo synthesis of arginine in humans. Am J Clin Nutr. 2008; 87 1282-1289
- 118 Coeffier M, Dechelotte P. Combined infusion of glutamine and arginine: does it make sense?. Curr Opin Clin Nutr Metab Care. 2010; 13 70-74
Priv.-Doz. Dr. med. Thomas W. Felbinger
Klinik für Anästhesiologie, operative Intensivmedizin und Schmerztherapie, Klinikum Neuperlach, Städtisches Klinikum München GmbH
Oskar-Maria-Graf-Ring 51
81377 München
Email: thomas.felbinger@klinikum-muenchen.de