Pharmacopsychiatry 2011; 44(4): 129-134
DOI: 10.1055/s-0031-1277166
Original Paper

© Georg Thieme Verlag KG Stuttgart · New York

Psychological and Neuroendocrine Responses to Social Stress and to the Administration of the alpha-2-Receptor Antagonist, Yohimbine, in Highly Trained Endurance Athletes in Comparison to Untrained Healthy Controls

M. Sommer1 , M. Braumann2 , T. Althoff1 , J. Backhaus3 , A. Kordon3 , K. Junghanns3 , D. Ehrenthal3 , U. Bartmann1 , F. Hohagen3 , A. Broocks1
  • 1Carl-Friedrich-Flemming-Klinik, HELIOS Kliniken Schwerin, Schwerin, Germany
  • 2Institut für Sportmedizin, Universität Hamburg, Hamburg, Germany
  • 3Klinik für Psychiatrie und Psychotherapie, Universität Lübeck, Lübeck, Germany
Weitere Informationen

Publikationsverlauf

received 09.12.2009 revised 22.03.2011

accepted 29.03.2011

Publikationsdatum:
27. Juni 2011 (online)

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Abstract

Introduction: Several clinical studies suggest antidepressive and anxiolytic effects of regular endurance training. The mechanisms by which exercise exerts these effects are still unclear. It was hypothesized that athletes might show a diminished reaction to psychosocial stress and noradrenergic stimulation.

Methods: 12 male athletes and 12 healthy untrained male controls underwent a challenge paradigm on 3 separate days: the alpha-2-receptor antagonist yohimbine (0.4 mg/kg), placebo or a psychosocial stress test (SST) were administered. Responses were measured by psychometric scales, plasma cortisol, blood pressure and heart rate.

Results: Before testing, psychometric variables and cortisol levels were not different between the 2 groups. In comparison to placebo conditions, both the social stress test and the administration of yohimbine were followed by significant increases of anxiety symptoms, plasma cortisol, heart rate and blood pressure in both groups. However, these responses were not significantly different between the group of athletes and the control group.

Discussion: These results do not support the hypotheses that high aerobic fitness is associated with attenuated psychological and neuroendocrine responses to yohimbine or to psychosocial stress.

References

Correspondence

Prof. Dr. med. A. Broocks

Wismarsche Straße 393–397

19049 Schwerin

Germany

Telefon: +49/385/520 3212

Fax: +49/385/520 2007

eMail: andreas.broocks@helios-kliniken.de