Download PDF
Int J Angiol 2007; 16(4): 139-142
DOI: 10.1055/s-0031-1278268
Original Articles

© Georg Thieme Verlag KG Stuttgart · New York

Occult left ventricular dysfunction diagnosed by myocardial performance index in patients with limb girdle muscle dystrophy: A case control study

Rajashekar R Gurrala1 , Venkata MB Alla2 , Wilbert S Aronow3 , Jai S Shankar1 , Meena K  Angamutta4 , Krishna SR Lanka1 , Sundaram Challa5 , Chandra K  Nair6
  • 1Department of Cardiology, Nizam's Institute of Medical Sciences, Hyderabad, India;
  • 2Department of Medicine, Creighton University School of Medicine, Omaha, Nebraska;
  • 3Division of Cardiology, New York Medical College, Valhalla, New York, USA;
  • 4Department of Neurology, Nizam's Institute of Medical Sciences, Hyderabad, India;
  • 5Department of Pathology, Nizam's Institute of Medical Sciences, Hyderabad, India;
  • 6Division of Cardiology, Creighton University School of Medicine, Omaha, Nebraska, USA
Further Information

Publication History

Publication Date:
27 April 2011 (online)

  PDF Download  Permissions and Reprints

Abstract

RR Gurrala, VMB Alla, WS Aronow, et al. Occult left ventricular dysfunction diagnosed by myocardial performance index in patients with limb girdle muscle dystrophy: A case control study. Int J Angiol 2007;16(4):139-142.

The myocardial performance index (MPI) was assessed in 30 patients with limb girdle muscle dystrophy (LGMD) with a normal left ventricular ejection fraction (greater than 50%), as well as in 30 age- and sex-matched healthy adults with a left ventricular ejection fraction greater than 50%. MPIs derived by pulsed-wave Doppler and tissue Doppler were also compared. The MPI was 0.37±0.09 in the LGMD patients and 0.29±0.09 in the control group (P=0.003). These data show that patients with LGMD have occult cardiac dysfunction as evidenced by a higher MPI than the controls. There was good agreement between the MPIs measured by pulsed-wave Doppler and tissue Doppler methods in these patients.

      >