Atherosclerosis in sickle cell disease - a review

Mohamed A Elsharawy; Khaled M Moghazy; Mohamed A Shawarby

doi:10.1055/s-0031-1278326

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Int J Angiol 2009; 18(2): 62-66
DOI: 10.1055/s-0031-1278326

Review Article

Atherosclerosis in sickle cell disease - a review

Mohamed A. Elsharawy¹ , Khaled M. Moghazy² , Mohamed A. Shawarby³

¹Department of Surgery, King Faisal University, Al-Khobar, Kingdom of Saudi Arabia
²Department of Radiology, King Faisal University, Al-Khobar, Kingdom of Saudi Arabia
³Department of Pathology, King Faisal University, Al-Khobar, Kingdom of Saudi Arabia

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Publikationsdatum:
28. April 2011 (online)

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Abstract

Acute, vaso-occlusive crises are the most common and earliest clinical manifestations of sickle cell disease. Recent thoughts about development of atherosclerosis as a result of this disease are presented. Current insights into the pathogenesis of atherosclerosis in sickle cell disease are reviewed, in particular the role of endothelial dysfunction, homo- cysteine and platelets. Common and uncommon sites of atherosclerosis are described. Radiological assessment and potential therapeutic agents to slow the progression of atherosclerosis are discussed. Finally, treatment of atherosclerosis in certain sites is evaluated and reviewed.