Abstract
Three new phenolic compounds, thamnoliadepsides A (1), B (2), and thamnolic acid A (3), and seven known compounds, everninic acid (4), baeomycesic acid (5), β-orcinol (6), β-resorcylic acid (7), ethyl orsellinate (8), squamatic acid (9), and vermicularin (10), were isolated from the lichen Thamnolia vermicularis (Sw.) Ach. ex Schaerer. Their structures were determined based on spectroscopic analysis, including 2D-NMR experiments and HR-MS techniques. Compound 1 inhibited growth of prostate cancer cells and bonded to G-quadruplex DNA based on NMR determination.
Key words
Thamnolia vermicularis
- Thamnoliaceae - depside - antiproliferative - G-quadruplex
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Prof. Dr. Hui-ming Hua
Key Laboratory of Structure-Based Drug Design & Discovery
Ministry of Education
School of Traditional Chinese Materia Medica
Shenyang Pharmaceutical University
Box 49
Shenyang 110016
People's Republic of China
Phone: +86 24 23 98 64 65
Fax: +86 24 23 98 64 65
Email: huimhua@163.com
