Planta Med 2012; 78(1): 86-89
DOI: 10.1055/s-0031-1280127
Natural Product Chemistry
Letters
© Georg Thieme Verlag KG Stuttgart · New York

Cytotoxic Triterpenoids from Berberis koreana

Ki Hyun Kim1 , Sang Un Choi2 , Kang Ro Lee1
  • 1Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, Suwon, Korea
  • 2Korea Research Institute of Chemical Technology, Daejeon, Korea
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Publikationsverlauf

received May 13, 2011 revised July 7, 2011

accepted July 11, 2011

Publikationsdatum:
16. September 2011 (online)

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Abstract

A bioassay-guided fractionation and chemical investigation of the trunk of Berberis koreana led to the isolation and identification of three new triterpenoids, 2α,3α,19α-trihydroxy-urs-12-en-24-formyl-28-oic acid (1), 2α,3β,21α-trihydroxy-urs-12-en-28-oic acid (2), and 3β-acetyloxy-1-oxo-olean-12-en-28-oic acid (3), along with seven known triterpenoids (410). The structures of these new compounds were determined through spectral analysis, including extensive 2D-NMR data. The new compounds 13 showed significant cytotoxicity against the A549, SK-OV-3, SK-MEL-2, and HCT-15 human tumor cell lines with IC50 values ranging from 7.17 to 48.73 µM.

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Prof. Dr. Kang Ro Lee

Natural Products Laboratory
School of Pharmacy
Sungkyunkwan University

300 Chonchon-dong, Jangan-ku

Suwon 440-746

Korea

Telefon: +82 31 2 90 77 10

Fax: +82 31 2 90 77 30

eMail: krlee@skku.ac.kr