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Planta Med 2012; 78(1): 36-38
DOI: 10.1055/s-0031-1280199
Biological and Pharmacological Activity
Letters
© Georg Thieme Verlag KG Stuttgart · New York

Inhibition of α-Glucosidase and Hypoglycemic Effect of Stilbenes from the Amazonian Plant Deguelia rufescens var. urucu (Ducke) A. M. G. Azevedo (Leguminosae)

Aline C. Pereira1 , Mara S. P. Arruda2 , Ewerton A. S. da Silva2 , Milton N. da Silva2 , Virgínia S. Lemos1 , Steyner F. Cortes3
  • 1Departamento de Fisiologia e Biofísica, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
  • 2Faculdade de Química, Instituto de Ciências Exatas e Naturais, Universidade Federal do Pará, Belém, Pará, Brazil
  • 3Departamento de Farmacologia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
Further Information

Publication History

received March 25, 2011 revised June 21, 2011

accepted August 8, 2011

Publication Date:
16 September 2011 (online)

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Abstract

The control of blood glucose levels is critical in the treatment of diabetes mellitus. α-Glucosidase inhibitors are of great importance in reducing hyperglycemia, and plants have provided many of these agents. The present study aimed at investigating the effect of two stilbenes, lonchocarpene and 3,5-dimethoxy-4′-O-prenyl-trans-stilbene (DPS), isolated from the Amazonian plant Deguelia rufescens var. urucu, on α-glucosidase activity and on mice postprandial hyperglycemia. Lonchocarpene and DPS inhibited α-glucosidase in vitro, with pIC50 values of 5.68 ± 0.12 and 5.73 ± 0.08, respectively. In addition, when given orally, DPS produced a significant reduction of hyperglycemia induced by an oral tolerance test, while lonchocarpene did not. Data suggest that DPS may have a potential use as an antidiabetic drug.

Key words

Deguelia rufescens var. urucu - Leguminosae - stilbenes - diabetes - α-glucosidase - plasma glucose

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Steyner F. Cortes

Department of Pharmacology
Instituto de Ciências Biológicas
Universidade Federal de Minas Gerais

Av. Antônio Carlos, 6627

31270-901, Belo Horizonte, MG

Brazil

Phone: +55 31 34 09 27 26

Fax: +55 31 34 09 26 95

Email: sfcortes@icb.ufmg.br