Phenols with Anti-HIV Activity from Daphne acutiloba

Abstract

The present paper describes the study of the phytochemical properties and anti-HIV activity of the phenolic isolates of the plateau medicinal plant Daphne acutiloba Rehd. (Thymelaeceae). Two new lignans named daphnenin (1) and daphnetone (2), along with 11 known ones, were isolated, and their structures were elucidated by 1D and 2D NMR spectroscopy as well as HR-ESI-MS. In the anti-HIV activity study, daphnenin (1) and caffeic acid n-octadecyl ester (13) showed definite anti-HIV activity with EC₅₀ values of 0.39 and 0.16 µg/mL, respectively.

Key words

Daphne acutiloba - Thymelaeceae - anti-HIV activity - phenols

References

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