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Planta Med 2012; 78(2): 148-153
DOI: 10.1055/s-0031-1280289
Natural Product Chemistry
Original Papers
© Georg Thieme Verlag KG Stuttgart · New York

Antibacterial Benzofuran Neolignans and Benzophenanthridine Alkaloids from the Roots of Zanthoxylum capense

Xuan Luo1 , Liliana Pedro1 , Vladimir Milic1 , 2 , Silva Mulhovo3 , Aida Duarte1 , Noélia Duarte1 , Maria-José U. Ferreira1
  • 1Research Institute for Medicines and Pharmaceutical Sciences (iMed.UL), Faculty of Pharmacy, University of Lisbon, Lisbon, Portugal
  • 2The School of Pharmacy, University of London, London, United Kingdom
  • 3Departamento de Ciências Agro–Pecuárias, Escola Superior Técnica, Universidade Pedagógica, Maputo, Mozambique
Further Information

Publication History

received June 21, 2011 revised Sept. 14, 2011

accepted Sept. 19, 2011

Publication Date:
14 October 2011 (online)

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Abstract

Two new 2-arylbenzofuran neolignans (1, 2) and a new benzophenanthridine alkaloid (3), together with six known benzophenanthridine alkaloids, namely, decarine (4), norchelerythrine (5), dihydrochelerythrine (6), 6-acetonyldihydrochelerythrine (7), tridecanonchelerythrine (8), and 6-acetonyldihydronitidine (9), have been isolated from the MeOH extract of the roots of Zanthoxylum capense. Their structures were elucidated by means of spectroscopic techniques including 2D NMR experiments. All the isolated compounds were evaluated for their in vitro antibacterial activity against gram-positive and gram-negative bacteria. Some compounds showed significant inhibitory activity against Staphylococcus aureus ATCC 6538 with MIC values ranging from 12.5 to 50 µg/mL.

Key words

Zanthoxylum capense (Thunb.) Harv. - Rutaceae - 2-arylbenzofuran neolignans - benzophenanthridine alkaloids - antibacterial activity - Staphylococcus aureus

Supporting Information

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Prof. Dr. Maria-José U. Ferreira

iMed.UL, Faculty of Pharmacy
University of Lisbon

Av. Prof. Gama Pinto

1649-003 LisbonPortugal

Phone: +351 21 7 94 64 75

Fax: +351 21 7 94 64 70

Email: mjuferreira@ff.ul.pt