Morning Glory Resin Glycosides as Modulators of Antibiotic Activity in Multidrug-Resistant Gram-Negative Bacteria

Abstract

Twenty-six microbiologically inactive (MIC > 512 µg/mL) convolvulaceous resin glycosides (1–26) were tested for resistance modulatory activity in vitro against Escherichia coli Rosetta-gami and two nosocomial pathogens, Salmonella typhi and Shigella flexneri. These compounds exerted a potentiation effect of the clinically useful antibiotics tetracycline, kanamycin, and chloramphenicol against the tested gram-negative bacteria by increasing antibiotic susceptibility up to 32-fold at concentrations of 25 µg/mL. Therefore, the oligosaccharides from the morning glory family (Convolvulaceae) represent metabolites that reverse microbial resistance mechanisms, favoring an increase in the strength and effectiveness of current antibiotics that are not effective in the treatment of refractive infections caused by multidrug-resistant strains.

Key words

resin glycosides - Convolvulaceae - Escherichia coli Rosetta-gami - Shigella flexneri - Salmonella typhi - multidrug resistance

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