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DOI: 10.1055/s-0031-1280311
© Georg Thieme Verlag KG Stuttgart · New York
Lignans from the Flower Buds of Magnolia liliflora Desr.
Publikationsverlauf
received February 16, 2011
revised Sept. 21, 2011
accepted Sept. 30, 2011
Publikationsdatum:
24. Oktober 2011 (online)

Abstract
Six new lignans, 1–6, along with six known compounds were obtained from the flower buds of Magnolia liliflora Desr. The new lignans were elucidated as (1S*,2R*,5S*,6S*)-2-(3,5-dimethoxyphenyl)-6-(3,4-methylenedioxyphenyl)-3,7-dioxabicyclo[3.3.0]octane (1), (1R*,2R*,5R*,6S*)-2-(3,5-dimethoxyphenyl)-6-(3,4-methylenedioxyphenyl)-3,7-dioxabicyclo[3.3.0]octane (2), (1R*, 2R*,5R*,6S*)-2,6-bis (3,5-dimethoxyphenyl)-3,7-dioxabicyclo[3.3.0]octane (3), (1R*,2S*,5R*,6R*)-2-(3,4-methylenedioxyphenyl)-6-(3,5-dimethoxyphenyl)-3,7-dioxabicyclo[3.3.0]octane (4), (7′S*,8R*,8′R*)-3,5′-dimethoxy-3′,4,9′-trihydroxy-7′, 9-epoxy-8,8′-lignan (5), and (7′R*,8′S*)-3,3′,4,5′-tetramethoxy-7-en-7′,9-epoxy-8,8′-lignan (6), by the analysis of 1D and 2D-NMR as well as HRESIMS data. The capacity of compound 1 to protect against damages to the DNA of rat lymphocyte cells induced by UV irradiation was assessed by the comet assay. It showed stronger antigenotoxicity than ascorbic acid from 6 × 10−3 mmol · L−1 to 6 × 10−6 mmol · L−1.
Key words
Magnoliaceae - Magnolia liliflora - lignan - antigenotoxicity - comet assay
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Dr. Wen-Shu Wang
College of Life and Environmental Sciences
Minzu University of China
Zhongguancun South Avenue 27#
Beijing 100081
P. R. China
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