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Planta Med 2012; 78(2): 154-159
DOI: 10.1055/s-0031-1280338
Natural Product Chemistry
Original Papers
© Georg Thieme Verlag KG Stuttgart · New York

Phosphodiesterase I-Inhibiting Diels-Alder Adducts from the Leaves of Morus mesozygia

Christian D. A. Fozing1 , 2 , Zulfiqar Ali2 , 3 , Bonaventure T. Ngadjui1 , M. Iqbal Choudhary2 , 4 , Gilbert D. W. F. Kapche5 , Berhanu M. Abegaz6 , Ikhlas A. Khan3
  • 1Department of Organic Chemistry, Faculty of Science, University of Yaounde I, Yaounde, Cameroon
  • 2H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan
  • 3National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS, USA
  • 4Department of Chemistry, College of Science, King Saud University, Riyadh, Saudi Arabia
  • 5Department of Chemistry, Higher Teacher Training College, University of Yaounde I, Yaounde, Cameroon
  • 6Department of Chemistry, Faculty of Science, University of Botswana, Gaborone, Botswana
Further Information

Publication History

received May 29, 2011 revised Sept. 13, 2011

accepted October 11, 2011

Publication Date:
14 November 2011 (online)

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Abstract

A new 2-arylbenzofuran derivative, (+)-dimethylsmoracin O (1), and three new Diels-Alder type adducts, mesozygins A–C (2–4), in addition to eight known compounds, artonin I (5), chalcomaracin (6), norartocarpetin (7), moracin L (8), mulberrofuran F (9), moracin M (10), moracin C (11), and morachalcone A (12), were isolated from the leaves of Morus mesozygia Stapf. Structures were elucidated by spectroscopic data analyses. Compounds 2–7 displayed a potent phosphodiesterase I inhibitory activity.

Key words

Morus mesozygia - Moraceae - Diels-Alder adducts - (+)-dimethylsmoracin O - mesozygins A–C - phosphodiesterase I inhibition

Supporting Information

References

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Dr. Zulfiqar Ali

National Center for Natural Products Research
School of Pharmacy
University of Mississippi

University, MS 38677

USA

Phone: +1 66 29 15 78 61

Email: zulfiqar@olemiss.edu

Dr. Gilbert D. W. F. Kapche

Department of Chemistry
Higher Teacher Training College
University of Yaounde I

P. O. Box 47

Yaounde 237

Cameroon

Phone: +2 37 77 66 49 73

Email: dkapche2002@yahoo.com