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Planta Med 2012; 78(3): 297-301
DOI: 10.1055/s-0031-1280449
Biological Screening
Original Papers
© Georg Thieme Verlag KG Stuttgart · New York

Screening the Antiangiogenic Activity of Medicinal Plants Grown and Sold in Jordan

Malek Zihlif1 , Fatma Afifi2 , Ruba Muhtaseb1 , Sondos Al-Khatib1 , Ismail Abaza2 , Randa Naffa1
  • 1Department of Pharmacology, Faculty of Medicine, University of Jordan, Amman, Jordan
  • 2Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Jordan, Amman, Jordan
Weitere Informationen

Publikationsverlauf

received October 10, 2011 revised October 19, 2011

accepted Nov. 24, 2011

Publikationsdatum:
15. Dezember 2011 (online)

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Abstract

Angiogenesis is essential for the growth, invasion, and metastasis of most solid tumors and has become a valuable pharmacological target for cancer prevention and treatment. This study was performed to assess the antiangiogenic activity of 31 medicinal plants grown and sold in Jordan. The antiangiogenic activity was assessed using the rat aortic ring assay. Out of 31 extracts, 15 extracts showed more than 50 % inhibition of the blood vessels outgrowth from the primary tissue explants (p = 0.000). Three of these 15 extracts showed a potential cytotoxic effect on normal fibroblast cells. Four extracts shared antiangiogenic and antiproliferative activity towards MCF7 breast cancer cell lines. Eight extracts demonstrated selective antiangiogenic activity. This is the first report demonstrating the potential antiangiogenic activity of Artemisia judaica, Aloysia citriodora, Salvia egyptiaca, and Calendula arvensis. Some extracts with antiangiogenic activity exhibited selectivity against the endothelial cells proliferation, demonstrating a direct inhibitory activity against the key step in tumor angiogenesis.

Key words

anti-angiogenesis - endothelial cells - MCF7 - plant extract - Jordan

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Dr. Malek Zihlif

Department of Pharmacology
Faculty of Medicine
University of Jordan

Amman 11942

Jordan

Telefon: +96 2 65 35 50 00

Fax: +96 2 65 35 67 46

eMail: M.zihlif@ju.edu.jo