Hepatic Radioembolization Complicated by Fulminant Hepatic Failure

ABSTRACT

A 68-year-old man with a history of metastatic colorectal carcinoma underwent left hepatic lobectomy and right hepatic wedge resection as initial treatment of his metastatic disease. He subsequently underwent right lobar radioembolization for treatment of a segment 8 lesion. At 6 weeks postembolization, he developed hepatic dysfunction which rapidly progressed to fulminant liver failure. A liver biopsy revealed hepatic venous obstruction and fibrosis. The patient died 14 weeks after radioembolization.

KEYWORDS

Hepatic failure - liver failure - fibrosis - radiation induced liver disease - transarterial embolization - radioembolization - yttrium-90 - metastatic disease - colorectal carcinoma

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