Aggressive Inverted Papilloma with Intracranial Invasion and Short Malignization Time

Peter Valentin Tomazic; Heinz Stammberger; Walter Habermann; Christoph Schmid; Wolfgang Koele; Michael Mokry; Verena Gellner; Alfred Beham

doi:10.1055/s-0031-1280738

Skull Base Rep 2011; 1(2): 111-114
DOI: 10.1055/s-0031-1280738

Aggressive Inverted Papilloma with Intracranial Invasion and Short Malignization Time

Peter Valentin Tomazic¹ , Heinz Stammberger¹ , Walter Habermann¹ , Christoph Schmid¹ , Wolfgang Koele¹ , Michael Mokry² , Verena Gellner² , Alfred Beham³

¹Department for General Otolaryngology, Head and Neck Surgery, Medical University Graz, Graz, Austria
²Department of Neurosurgery, Medical University Graz, Graz, Austria
³Institute of Pathology, Medical University Graz, Graz, Austria

Abstract

ABSTRACT

Inverted papillomas (IP) are considered benign lesions with a prevalence up to 4% among all sinunasal tumors; however, invasive growth and varying tendency for malignization are reported in literature. We report the case of a 69-year-old woman suffering from a large, aggressively growing IP invading the orbit, skull base, and frontal lobe of the brain. Within only 3 months' time the papilloma showed transformation into an invasive carcinoma, leaving surgical therapy in vain due to explosive recurrence. Intracranial and intraorbital expansion by IP is possible despite histology not showing signs of malignancy initially. In “regular” IP close endoscopic follow-up is mandatory to not overlook recurrence harboring malignancy.

KEYWORDS

Inverted papilloma - endoscopic surgery - rapid malignization - intracranial involvement

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References

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Peter Valentin TomazicM.D.

ENT-University Hospital Graz, Medical University Graz

Auenbruggerplatz 26/28, 8036 Graz, Austria

Email: peter.tomazic@medunigraz.at