Solid Pseudopapillary Tumors of the Pancreas: A Case Series, Comparison of Histopathological and Clinical Data

Zusammenfassung

Solide pseudopapilläre Tumoren des Pankreas sind seltene Neoplasien dieses Organs. Sie werden zumeist zufällig diagnostiziert und treten prädominant bei Frauen auf. Die Prognose ist sehr gut. In der vorliegenden Fallserie werden der klinische Verlauf und die pathohistologischen Daten von 8 Patienten (7 weibliche, 1 männlicher Patient) beschrieben und mit den bisher publizierten Fallstudien verglichen auch im Hinblick auf klinische und pathologische Differenzialdiagnosen einer soliden Pankreasraumforderung. Pathohistologisch und immunhistochemisch zeigte sich ein vergleichbares Ergebnis in allen 8 Fällen auch unter Berücksichtigung der aktuellen Literatur. Obwohl hier einzelne Fälle mit schlechter Prognose beschrieben wurden, sind aktuell bei den vorgestellten Patienten keine Rezidive oder Metastasen bekannt.

Abstract

Solid pseudopapillary neoplasms (SPNs) are rare pancreatic tumors. They occur most frequently in young females and are often diagnosed accidentally. SPNs are characterized by an excellent clinical outcome. In our case series the clinical course, pathohistological data and clinical outcome of eight patients (7 female patients, 1 male patient) with SPN are described. Histological examination as well as immunohistochemical analysis shows similar results in all eight cases. Although in the literature a few cases of SPNs with bad prognosis have been reported, up to now none of our patients shows any signs of recurrence or metastasis. Moreover, we give in this case series a summary of SPNs in the literature, important clinical and pathological differential diagnosis, and additionally discuss relevant differential diagnosis occurring in daily routine work.

Schlüsselwörter

solide pseudopapilläre Tumoren des Pankreas - gastro-entero-pankreatische Tumoren - Pankreas - Immunhistochemie - Neuroendokriner Tumor - Azinuszellkarzinom

Key words

solid pseudopapillary tumor - Frantz tumor - pancreas - immunohistochemistry - neuroendocrine tumor - acinar cell carcinoma

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