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Int J Sports Med 2011; 32(12): 987-991
DOI: 10.1055/s-0031-1283186
Genetics & Molecular Biology
© Georg Thieme Verlag KG Stuttgart · New York

Is the C34T Polymorphism of the AMPD1 Gene Associated with Athlete Performance in Rowing?

P. Ciȩszczyk
1   Institute of Physical Culture, University of Szczecin, Poland
,
J. Eider
2   Faculty of Physical Culture and Health Promotion, University of Szczecin, Poland
,
M. Ostanek
3   Department of Clinical and Molecular Biochemistry, Pomeranian Medical University in Szczecin, Poland
,
A. Leońska-Duniec
4   Department of Genetics, University of Szczecin, Poland
,
K. Ficek
5   Department of Health, Galen Medical Center, Bierun, Poland
,
K. Kotarska
2   Faculty of Physical Culture and Health Promotion, University of Szczecin, Poland
,
G. Girdauskas
6   Faculty of Team Sports, Lithuanian Academy of Physical Education, Kaunas, Lithuania
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accepted after revision 24. Mai 2011

Publikationsdatum:
21. November 2011 (online)

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Abstract

The skeletal muscle-specific isoform of adenosine monophosphate deaminase (AMPD) is one of the most important regulators of muscle energy metabolism. A nonsense C to T transition in nucleotide 34 (C34T) in exon 2 of AMPD1 gene converts the codon CAA into the premature stop-codon TAA. 127 Polish male rowers including Olympic and world champions were recruited for this study. Controls samples were obtained from 251 unrelated volunteers. Statistically significant differences in genotype distribution were observed when only a whole group of rowers (88.19% CC, 11.81% CT, 0% TT; p=0.009) were compared with controls (75.31% CC, 23.10% CT, 1,59% TT). A significant deficiency of the T allele compared to control samples was noted in the elite rowers (4.55%, p=0.021) and non-elite rowers (6.63%, p=0.023), whereas this trend was even stronger when compared with the controls for the whole group of rowers (5.91%, p=0.002). Our results suggest that the T allele is associated with physical performance level, therefore, it may be included in the group of performance altering polymorphisms as a negative factor to athletic performance.

Key words

AMPD - genotype - rowing - athlete performance
 

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