Bordetella bronchiseptica Pneumonia in an Extremely-Low-Birth-Weight Neonate

Abstract

Bordetella bronchiseptica, a gram-negative coccobacillus, is a common veterinary pathogen. In both domestic and wild animals, this bacterium causes respiratory infections including infectious tracheobronchitis in dogs and atrophic rhinitis in swine. Human infections are rare and have been documented in immunocompromised hosts. Here, we describe an extremely-low-birth-weight infant with B. bronchiseptica pneumonia. This is the first report that describes the microorganism's responsibility in causing nosocomial infection in a preterm neonate. He recovered uneventfully after a course of meropenem. It is possible that the bacteria colonize the respiratory tracts of our health care workers or parents who may have had contact with pets and then transmitted the bacterium to our patient. Follow-up until 21 months of age showed normal growth and development. He did not suffer from any significant residual respiratory disease.

Keywords

Bordetella bronchiseptica - extremely low birth weight - preterm - neonate

• References

• 1 Woolfrey BF, Moody JA. Human infections associated with Bordetella bronchiseptica . Clin Microbiol Rev 1991; 4: 243-255
• 2 Mattoo S, Cherry JD. Molecular pathogenesis, epidemiology, and clinical manifestations of respiratory infections due to Bordetella pertussis and other Bordetella subspecies. Clin Microbiol Rev 2005; 18: 326-382
• 3 Ner Z, Ross LA, Horn MV , et al. Bordetella bronchiseptica infection in pediatric lung transplant recipients. Pediatr Transplant 2003; 7: 413-417
• 4 Wallet F, Perez T, Armand S, Wallaert B, Courcol RJ. Pneumonia due to Bordetella bronchiseptica in a cystic fibrosis patient: 16S rRNA sequencing for diagnosis confirmation. J Clin Microbiol 2002; 40: 2300-2301
• 5 Parkhill J, Sebaihia M, Preston A , et al. Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica . Nat Genet 2003; 35: 32-40
• 6 Gueirard P, Guiso N. Virulence of Bordetella bronchiseptica: role of adenylate cyclase-hemolysin. Infect Immun 1993; 61: 4072-4078
• 7 Tuomanen EI, Nedelman J, Hendley JO, Hewlett EL. Species specificity of Bordetella adherence to human and animal ciliated respiratory epithelial cells. Infect Immun 1983; 42: 692-695
• 8 Dworkin MS, Sullivan PS, Buskin SE , et al. Bordetella bronchiseptica infection in human immunodeficiency virus-infected patients. Clin Infect Dis 1999; 28: 1095-1099
• 9 Gomez L, Grazziutti M, Sumoza D, Beran M, Rolston K. Bacterial pneumonia due to Bordetella bronchiseptica in a patient with acute leukemia. Clin Infect Dis 1998; 26: 1002-1003
• 10 Huebner ES, Christman B, Dummer S, Tang YW, Goodman S. Hospital-acquired Bordetella bronchiseptica infection following hematopoietic stem cell transplantation. J Clin Microbiol 2006; 44: 2581-2583
• 11 Spilker T, Liwienski AA, LiPuma JJ. Identification of Bordetella spp. in respiratory specimens from individuals with cystic fibrosis. Clin Microbiol Infect 2008; 14: 504-506
• 12 Barrio VR, Darmstadt GL. Rash and opportunistic pneumonia in a malnourished infant adopted from China. Clin Infect Dis 2000; 30: 408-409
• 13 Lariviere S, Leblanc L, Mittal KR, Martineau GP. Comparison of isolation methods for the recovery of Bordetella bronchiseptica and Pasteurella multocida from the nasal cavities of piglets. J Clin Microbiol 1993; 31: 364-367
• 14 Rath BA, Register KB, Wall J, Sokol DM, Van Dyke RB. Persistent Bordetella bronchiseptica pneumonia in an immunocompetent infant and genetic comparison of clinical isolates with kennel cough vaccine strains. Clin Infect Dis 2008; 46: 905-908
• 15 Brockmeier SL, Lager KM. Experimental airborne transmission of porcine reproductive and respiratory syndrome virus and Bordetella bronchiseptica . Vet Microbiol 2002; 89: 267-275
• 16 Galeziok M, Roberts I, Passalacqua JA. Bordetella bronchiseptica pneumonia in a man with acquired immunodeficiency syndrome: a case report. J Med Case Reports 2009; 3: 76-