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Horm Metab Res 2011; 43(09): 646-652
DOI: 10.1055/s-0031-1284352
Humans, Clinical
© Georg Thieme Verlag KG Stuttgart · New York

Maintained Serum Sodium in Male Ultra-Marathoners – The Role of Fluid Intake, Vasopressin, and Aldosterone in Fluid and Electrolyte Regulation

J. Bürge
1   Institute of General Practice and Health Services Research, University of Zurich, Zurich, Switzerland
,
B. Knechtle
1   Institute of General Practice and Health Services Research, University of Zurich, Zurich, Switzerland
2   Gesundheitszentrum St. Gallen, St. Gallen, Switzerland
,
P. Knechtle
2   Gesundheitszentrum St. Gallen, St. Gallen, Switzerland
,
M. Gnädinger
1   Institute of General Practice and Health Services Research, University of Zurich, Zurich, Switzerland
,
C. A. Rüst
1   Institute of General Practice and Health Services Research, University of Zurich, Zurich, Switzerland
,
T. Rosemann
1   Institute of General Practice and Health Services Research, University of Zurich, Zurich, Switzerland
› Institutsangaben
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Publikationsverlauf

received 22. Februar 2011

accepted 30. Juni 2011

Publikationsdatum:
05. August 2011 (online)

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Erratum zu diesem Artikel:

Maintained Serum Sodium in Male Ultra-Marathoners – The Role of Fluid Intake, Vasopressin, and Aldosterone in Fluid and Electrolyte RegulationHorm Metab Res 2011; 43(09): e1-e1
DOI: 10.1055/s-0032-1322555

Erratum zu diesem Artikel:

Maintained Serum Sodium in Male Ultra-Marathoners – The Role of Fluid Intake, Vasopressin, and Aldosterone in Fluid and Electrolyte RegulationHorm Metab Res 2012; 44(09): 711-711
DOI: 10.1055/s-0032-1325139

Abstract

Exercise-associated hyponatremia (EAH) is a well know electrolyte disorder in endurance athletes. Although fluid overload is the most like etiology, recent studies, however, argued whether EAH is a disorder of vasopressin secretion. The aims of the present study were to investigate (i) the prevalence of EAH in male ultra-marathoners and (ii) whether fluid intake, aldosterone or vasopressin, as measured by copeptin, were associated with post-race serum sodium concentration ([Na+]). In 50 male ultra-marathoners in a 100 km ultra-marathon, serum [Na+], aldosterone, copeptin, serum and urine osmolality, and body mass were measured pre- and post-race. Fluid intake, renal function parameters and urine excretion were measured. No athlete developed EAH. Copeptin and aldosterone increased; a significant correlation was found between the change in copeptin and the change in serum [Na+], no correlation was found between aldosterone and serum [Na+]. Serum [Na+] increased by 1.6%; body mass decreased by 1.9 kg. The change in serum [Na+] and body mass correlated significantly and negatively. The fluid intake of ~ 0.58 l/h was positively related to the change in body mass and negatively to both post-race serum [Na+] and the change in serum [Na+]. We conclude that serum [Na+] was maintained by both the mechanisms of fluid intake and the hormonal regulation of vasopressin.

Key words

electrolytes - aldosterone - vasopressin - ultra-endurance
 

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