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Horm Metab Res 2011; 43(09): 593-600
DOI: 10.1055/s-0031-1284353
Review
Georg Thieme Verlag KG Stuttgart · New York

Prolactin and Lactation as Modifiers of Diabetes Risk in Gestational Diabetes

M. A. Ramos-Román
1   University of Texas Southwestern Medical Center, Dallas, TX, USA
› Author Affiliations
Further Information

Publication History

received 04 May 2011

accepted 30 June 2011

Publication Date:
05 August 2011 (online)

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Abstract

Pregnancy and puerperium are periods of intense hormonal changes. Maternal metabolism adapts to spare the mother from harm on behalf of her developing offspring and major alterations maintain normal glucose tolerance. Insulin secretion increases during a normal pregnancy to compensate for pregnancy-induced insulin resistance and maintain euglycemia. Women at risk for gestational diabetes have insulin resistance before conception. Gestational diabetes develops when a woman at risk is unable to meet the insulin secretory demands imposed by the additional insulin resistance characteristic of pregnancy. The lactogens, human placental lactogen and prolactin, are major stimuli for the adaptation of the endocrine pancreas during gestation. This review discusses the role of lactogens on glucose homeostasis during pregnancy and proposes a mechanism by which the hormonal control of lactation, led by prolactin, may regulate adipocyte biology, glucose and lipid metabolism, and guard postpartum women against type 2 diabetes.

Key words

breastfeeding - hyperprolactinemia - pregnancy - puerperium
 

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