Impact of Smoking during Pregnancy on Functional Coagulation Testing

Donna Dizon-Townson; Connie Miller; Valerija Momirova; Baha Sibai; Catherine Y. Spong; George Wendel Jr.; Katharine Wenstrom; Philip Samuels; Steve Caritis; Yoram Sorokin; Menachem Miodovnik; Mary J. O'Sullivan; Deborah Conway; Ronald J. Wapner; Steven G. Gabbe

doi:10.1055/s-0031-1285097

American Journal of Perinatology, Table of Contents

Am J Perinatol 2012; 29(03): 225-230
DOI: 10.1055/s-0031-1285097

Original Article

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Impact of Smoking during Pregnancy on Functional Coagulation Testing

Donna Dizon-Townson

¹Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, Utah

,

Connie Miller

²Hemostasis Laboratory, Centers for Disease Control and Prevention, Atlanta, Georgia

,

Valerija Momirova

³Biostatistics Coordinating Center, George Washington University, Washington, D.C.

,

Baha Sibai

⁴Department of Obstetrics and Gynecology, University of Cincinnati, Cincinnati, Ohio

,

Catherine Y. Spong

⁵Eunice Kennedy Shriver National Institute of Child Health and Human Development, Pregnancy and Perinatology Branch, Bethesda, Maryland

,

George Wendel Jr.

⁶Department of Obstetrics and Gynecology, University of Texas–Southwestern, Dallas, Texas

,

Katharine Wenstrom

⁷Brown University, Providence, Rhode Island

⁸Women and Infants Hospital of Rhode Island, Providence, Rhode Island

,

Philip Samuels

⁹The Ohio State University, Columbus, Ohio

,

Steve Caritis

¹⁰Department of Maternal-Fetal Medicine, Magee Women's Research Institute, Pittsburgh, Pennsylvania

,

Yoram Sorokin

¹⁴Division of Maternal-Fetal Medicine, Wayne State University School of Medicine, Detroit, Michigan; for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network, Bethesda, Maryland

,

Menachem Miodovnik

⁴Department of Obstetrics and Gynecology, University of Cincinnati, Cincinnati, Ohio

,

Mary J. O'Sullivan

¹¹University of Miami, Coral Gables, Florida; Department of Obstetrics and Gynecology, San Antonio, Texas

,

Deborah Conway

¹²School of Medicine–UT Health Science Center at San Antonio, San Antonio, Texas

,

Ronald J. Wapner

¹³Columbia University, New York City, New York

,

Steven G. Gabbe

⁹The Ohio State University, Columbus, Ohio

› Author Affiliations

Abstract

Compounds that are systemically absorbed during the course of cigarette smoking, and their metabolites, affect the coagulation system and cause endothelial dysfunction, dyslipidemia, and platelet activation leading to a prothrombotic state. In addition, smoking increases the activity of fibrinogen, homocysteine, and C-reactive protein. We hypothesize that smoking may affect functional coagulation testing during pregnancy. A secondary analysis of 371 women pregnant with a singleton pregnancy and enrolled in a multicenter, prospective observational study of complications of factor V Leiden mutation subsequently underwent functional coagulation testing for antithrombin III, protein C antigen and activity, and protein S antigen and activity. Smoking was assessed by self-report at time of enrollment (<14 weeks). None of the functional coagulation testing results was altered by maternal smoking during pregnancy. Smoking does not affect the aforementioned functional coagulation testing results during pregnancy.

Keywords

coagulation - smoking - pregnancy - factor V Leiden

Full Text

References

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