New Reactions Exploring the Chemical Spaces of the Aldol Addition of Active Methylene Compounds

Abstract

During research planning and the development of ideas, organic chemists intuitively work on the chemical space, even if they are often unaware of the nature and the extent of chemical space of organic reactions, in which they are moving. The exploration and the rational analysis of new chemical spaces originating from new tandem and multicomponent aldol additions of active methylene compounds can lead to the development of new efficient and environmentally friendly methodologies and to the synthesis of new libraries of highly functionalised compounds.

1 Introduction

2 Chemical Space of the Aldol Addition of Active Methylene Compounds

3 One-Pot Tandem Aldol Addition-Cyclization Reactions

4 Analysis of Chemical Spaces

aldol addition - active methylene compounds - tandem aldol addition-cyclization - multicomponent reactions

References and Notes

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