Abstract
A library of heterocyclic products with a wide variety of organic
residues is produced via a four-component reaction of α,β-unsaturated
aldehydes, primary amines, carbon monoxide, and ethylene using a
multi-reactor station with an array of 96 autoclaves employing the
same high-pressure reaction conditions for all catalytic reactions.
In the presence of Ru3(CO)12 as a precatalyst,
mixtures of chiral γ-lactams and 2,3-disubstituted pyrroles
are obtained. This combinatorial approach also enables us for the
first time to set up rules relating to the effects of specific substituents
in the substrates on the outcome of the respective catalytic reaction.
Key words
ruthenium - C-H activation - catalysis - γ-lactams - pyrroles
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