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Synthesis 2012(4): 527-531
DOI: 10.1055/s-0031-1289623
DOI: 10.1055/s-0031-1289623
PSP
© Georg Thieme Verlag
Stuttgart ˙ New York
An Environmentally Friendly Synthesis of Michler’s Ketone Analogues in Water
Further Information
Received
26 September 2011
Publication Date:
24 November 2011 (online)
Publication History
Publication Date:
24 November 2011 (online)
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Abstract
An environmentally friendly method for the synthesis of a series of novel, unsymmetrical Michler’s ketone analogues, [4-(dialkylamino)phenyl](aryl)methanones, via nucleophilic aromatic substitution of (fluorophenyl)(aryl)methanones with various amines in water is described. The reaction products are formed in high yields and additional purification is not required. The aqueous solvent and unreacted amines can be recycled.
Key words
Michler’s ketone - nucleophilic substitution - environmentally friendly - secondary amines - water
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