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Synthesis 2012(2): 219-234  
DOI: 10.1055/s-0031-1289649
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Functionalized 3,4-Diarylbenzophenones and 2,4-Diarylbenzophenones by Site-Selective Suzuki and Sonogashira Cross-Coupling Reactions of Bis(triflates) of 3,4- and 2,4-Dihydroxybenzophenone

Rasheed Ahmed Kheraa,b, Muhammad Nawaza,c, Holger Feista, Alexander Villingera, Peter Langer*a,d
a Institut für Chemie, Universität Rostock, Albert-Einstein-Str. 3a, 18059 Rostock, Germany
Fax: +49(381)4986412; e-Mail: peter.langer@uni-rostock.de;
b Department of Chemistry and Biochemistry, University of Agriculture, Faisalabad, Pakistan
c Department of Chemistry, Comsats Institute of Information Technology, Campus Abbottabad, Abbottabad, Pakistan
d Leibniz-Institut für Katalyse e. V. an der Universität Rostock, Albert-Einstein-Str. 29a, 18059 Rostock, Germany
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Publikationsverlauf

Received 9 June 2011
Publikationsdatum:
15. Dezember 2011 (online)

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Abstract

Palladium(0)-catalyzed Suzuki and Sonogashira cross-coupling reactions of the bis(triflates) of 2,4- and 3,4-dihydroxybenzophenone afforded 2,4- and 3,4-diarylbenzophenones, respectively. The reactions proceeded with very good site-selectivity in favor of position 4.

Key words

benzophenone - cross-coupling - palladium - site-selectivity - Suzuki reaction - Sonogashira reaction

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1

Authors R.A.K. and M.N. contributed equally to this manuscript.

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CCDC-853438 (8) and CCDC-853439 (14c) contain all crystallographic details of this publication and are available free of charge at www.ccdc.cam.ac.uk/conts/retrieving.html or can be ordered from the following address: Cambridge Crystallographic Data Centre, 12 Union Road, Cambridge CB2 1EZ, UK; Fax: +44 (1223)336033; or email: deposit@ccdc.cam.ac.uk.