Extending Triazolyl-Based Release under Mildly Acidic Conditions To Give Aniline Derivatives

Abstract

Triazolyl derivatives of anilines were prepared and evaluated as releasing systems at mildly acidic pH values. Two triazolyl derivatives showed convenient pH sensitivity, being stable at pH 7.3 and rapidly hydrolyzed at pH values below 5. A generalized mechanism is proposed from additional theoretical investigations.

hydrolysis - alkynes - azides - cycloaddition - amines - protonation

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