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Synthesis 2012; 44(11): 1718-1724
DOI: 10.1055/s-0031-1289759
DOI: 10.1055/s-0031-1289759
paper
Synthesis of Thymidine Dimers from 5′-O-Aminothymidine
Further Information
Publication History
Received: 20 February 2012
Accepted after revision: 28 March 2012
Publication Date:
09 May 2012 (online)
Abstract
The synthesis of modified oligonucleotides is of great importance for various therapeutic and diagnostic applications. The facile secondary structure formation of N-oxyamide-linked peptide analogues and the high nucleophilicity of the aminooxy function prompted us to prepare O-amino nucleoside derived dinucleosides. Herein, the efficient synthesis of three novel thymidine dimers with N-oxyamide, oxime and oxyamine linkages via a convergent approach from a common 5′-O-aminothymidine is reported.
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