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Synthesis 2012; 44(15): 2359-2364
DOI: 10.1055/s-0031-1289812
DOI: 10.1055/s-0031-1289812
paper
A New Approach to the Synthesis of Acyclic Nucleotide Phosphonate Analogues with Triple or Double Bonds
Further Information
Publication History
Received: 26 March 2012
Accepted after revision: 14 May 2012
Publication Date:
26 June 2012 (online)
Abstract
On the basis of new methodology to design the phosphonate analogues of nucleotides, the first series of acyclic nucleotides possessing a triple bond in the carbon skeleton were prepared by coupling diethyl 4-chlorobuta-1,2-dienylphosphonate with the corresponding purine or pyrimidine nucleic bases under base-catalyzed alkylation conditions.
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