Abstract
The preparation of optically active morpholine-2-aryl-2-acetaldehyde
from morpholine-2-aryl-3-one is reported. The quaternary carbon
is introduced during a palladium-promoted asymmetric allylic alkylation.
This is a useful intermediate in the synthesis and development of
potent NK antagonist.
Key words
alkylation - palladium - asymmetric catalysis - heterocycle
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