Synlett 2011(20): 3018-3022  
DOI: 10.1055/s-0031-1289893
LETTER
© Georg Thieme Verlag Stuttgart ˙ New York

Synthetic Studies toward 3-(Acylamino)-1H-indazoles and Development of a One-Pot, Microwave-Assisted, Oxadiazole Condensation/Boulton-Katritzky Rearrangement

Gregory R. Ott*, Andrew V. Anzalone
Department of Medicinal Chemistry, Cephalon, Inc., 145 Brandywine Parkway, West Chester, PA 19380, USA
Fax: +1(610)3440065; e-Mail: gott@cephalon.com;
Further Information

Publication History

Received 21 September 2011
Publication Date:
23 November 2011 (online)

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Abstract

Studies on the Boulton-Katritzky rearrangement of 3-(2-aminoaryl)-1,2,4-oxadiazoles have led to the identification of additional electronic factors that govern the rearrangement as well as a competitive thermal rearrangement pathway for select substrates. To circumvent the limitations of the conventional thermal conversion sequence an improved protocol that employs microwave irradiation has been devised that allows access to rearrangement products in good to excellent isolated yields. Furthermore, we have developed a two-component, one-pot sequence using a microwave-assisted oxadiazole condensation/Boulton-Katritzky rearrangement to deliver 3-(acylamino)-1H-indazoles from simple esters and 2-amino-N-hydroxy-benzamidine