The stereoselective total synthesis of a phytotoxic macrolide
putaminoxin, isolated from the culture of Phoma
putaminum fungus, has been accomplished by utilization of Sharpless
asymmetric epoxidation, Birch reduction, Jacobsen’s kinetic
resolution of racemic epoxide, and Yamaguchi lactonization as key
transformations.
macrolide - necrotic leaf disease - Sharpless
asymmetric epoxidation - Birch reduction - Jacobsen’s
kinetic resolution - Yamaguchi lactonization