Copper-Catalyzed Cross-Coupling of O-Alkyl Hydroxamates with Aryl Iodides

Abstract

N-Aryl-O-alkylhydroxamic acid derivatives were prepared by copper-catalyzed cross-coupling of hydroxamates with aryl iodides. The reaction conditions are compatible with standard hydroxy-protecting groups on the hydroxylamine moiety and are applicable to a broad range of coupling partners.

Key words

copper - arylation - cross-coupling - amides - halides - catalysis

• References

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