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Synlett 2012; 23(16): 2298-2310
DOI: 10.1055/s-0031-1290460
DOI: 10.1055/s-0031-1290460
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The Chemistry and Biology of Nakiterpiosin – C-nor-D-Homosteroids
Further Information
Publication History
Received: 18 May 2012
Accepted after revision: 17 July 2012
Publication Date:
14 September 2012 (online)
Abstract
Isolated from the sponge Terpios hoshinota that causes coral black disease, nakiterpiosin was the first C-nor-D-homosteroid discovered from a marine source. We provide in this account an overview of the chemistry and biology of this natural product. We also include a short history of the synthesis of C-nor-D-homosteroids and the results of some unpublished biological studies of nakiterpiosin.
1 Introduction
2 Synthesis of C-nor-D-Homosteroids
2.1 The Biomimetic Approaches
2.2 The Ring-by-Ring Approaches
2.3 Miscellaneous Approaches
3 Structural Revision of Nakiterpiosin
4 Synthesis of Nakiterpiosin
5 Biology of Nakiterpiosin
6 Conclusion
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References
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