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Synlett 2012(6): 930-934  
DOI: 10.1055/s-0031-1290502
LETTER
© Georg Thieme Verlag Stuttgart ˙ New York

Copper-Catalyzed Coupling of Alkynes with Alkenyl Halides

Yun-Yung Lin, Yu-Jen Wang, Jun-Hao Cheng, Chin-Fa Lee*
Department of Chemistry, National Chung Hsing University, Taichung, Taiwan 402, Republic of China
Fax: +886(4)22862547; e-Mail: cfalee@dragon.nchu.edu.tw;
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Publication History

Received 1 December 2011
Publication Date:
15 March 2012 (online)

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Abstract

The synthesis of enynes from the coupling of terminal alkynes with alkenyl iodides and bromides is described. This system employs 1.0-5.0 mol% of CuI(Xantphos) as a catalyst. A variety of alkenyl iodides and bromides are coupled smoothly with terminal alkynes, affording enynes in good to excellent yields.

Key words

copper - cross-coupling - terminal alkyne - alkenyl halide - enyne

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