An Efficient One-Pot Access
to Quinazolinone Derivatives Using TiO2 Nanoparticles
as Catalyst: Synthesis and Vasorelaxant Activity Evaluation

Ali Khalafi-Nezhad; Saghar Mowlazadeh Haghighi; Azar Purkhosrow; Farhad Panahi

doi:10.1055/s-0031-1290610

LETTER

An Efficient One-Pot Access to Quinazolinone Derivatives Using TiO₂ Nanoparticles as Catalyst: Synthesis and Vasorelaxant Activity Evaluation

Ali Khalafi-Nezhad*^a, Saghar Mowlazadeh Haghighi^a, Azar Purkhosrow^b, Farhad Panahi*^a
^a Chemistry, Shiraz University, Shiraz 71454, Iran
Fax: +98(711)2280926; e-Mail: khalafi@chem.susc.ac.ir; e-Mail: panahi@shirazu.ac.ir;
^b Cardiovascular Pharmacology Research Lab, Department of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz 71454, Iran

Abstract

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Abstract

A variety of quinazolinone derivatives were successfully synthesized, via a three-component condensation reaction between anthranilic acid, acetic anhydride, and amines. This process was accomplished in the presence of catalytic amount of titanium dioxide nanoparticles (nano-TiO₂), under solvent-free conditions. The synthesized compounds were evaluated for their vasorelaxant activity as they revealed a range of activities on the isolated thoracic rat aorta.

Key words

quinazolinone - multicomponent reaction - TiO₂ nanoparticles - heterogeneous catalyst - vasorelaxant activity

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Referenzen

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See Supporting Information.

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Zusatzmaterial

Supporting Information

An Efficient One-Pot Access to Quinazolinone Derivatives Using TiO2 Nanoparticles as Catalyst: Synthesis and Vasorelaxant Activity Evaluation

An Efficient One-Pot Access to Quinazolinone Derivatives Using TiO₂ Nanoparticles as Catalyst: Synthesis and Vasorelaxant Activity Evaluation