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Synthesis 2012; 44(8): 1208-1212
DOI: 10.1055/s-0031-1290768
DOI: 10.1055/s-0031-1290768
paper
Synthesis of Phloroglucinol Monoaryl Ethers
Further Information
Publication History
Received: 13 January 2012
Accepted after revision: 21 February 2012
Publication Date:
27 March 2012 (online)
Abstract
A variety of novel functionalized phloroglucinol monoaryl ethers have been synthesized using a two-step procedure. Target ethers were synthesized by coupling electron-deficient aryl fluorides with 3,5-dimethoxyphenol via nucleophilic aromatic substitution (SNAr) in N-methylpyrrolidone and cesium carbonate. Subsequent boron tribromide-mediated demethylation gave a series of phloroglucinol monoaryl ethers in good overall yields.
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