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Synthesis 2012; 44(10): 1577-1583
DOI: 10.1055/s-0031-1290772
DOI: 10.1055/s-0031-1290772
paper
An Efficient One-Pot Synthesis of 3,5-Disubstituted 1H-Pyrazoles
Weitere Informationen
Publikationsverlauf
Received: 01. Dezember 2011
Accepted after revision: 29. Februar 2012
Publikationsdatum:
19. April 2012 (online)
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Abstract
An efficient, general, one-pot, three-component procedure for the preparation of 3,5-disubstituted 1H-pyrazoles via condensation of substituted aromatic aldehydes, tosylhydrazine and terminal alkynes in toluene is reported. The reaction tolerates a variety of functional groups and sterically hindered substrates to afford the desired pyrazoles in yields of 67–91%.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
- Supporting Information
-
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